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Biotin-PEG2-acid

  CAS No.: 1365655-89-5   Cat No.: BADC-00935   Purity: >98.0% 4.5  

Biotin-PEG2-acid combines a biotin tag with a short PEG linker, ideal for ADCs and affinity-based purification. It enables avidin-biotin interaction, facilitating antibody targeting, detection, or capture in bioconjugation and drug delivery applications.

Biotin-PEG2-acid

Structure of 1365655-89-5

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Category
ADC Linker
Molecular Formula
C17H29N3O6S
Molecular Weight
403.49
Shipping
Room temperature, or blue ice upon request.
Shipping
-20°C

* For research and manufacturing use only. We do not sell to patients.

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Synonyms
(+)-Biotin-PEG2-acid; (+)-Biotin-PEG2-COOH; 3-(2-(2-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)ethoxy)ethoxy)propanoic acid
IUPAC Name
3-[2-[2-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]ethoxy]ethoxy]propanoic acid
Canonical SMILES
C1C2C(C(S1)CCCCC(=O)NCCOCCOCCC(=O)O)NC(=O)N2
InChI
InChI=1S/C17H29N3O6S/c21-14(18-6-8-26-10-9-25-7-5-15(22)23)4-2-1-3-13-16-12(11-27-13)19-17(24)20-16/h12-13,16H,1-11H2,(H,18,21)(H,22,23)(H2,19,20,24)/t12-,13-,16-/m0/s1
InChIKey
SDOAIZRTYJIBBG-XEZPLFJOSA-N
Density
1.2±0.1 g/cm3
Solubility
10 mm in DMSO
Flash Point
408.7±32.9 °C
Index Of Refraction
1.527
Vapor Pressure
0.0±5.4 mmHg at 25°C
Appearance
Solid
Shelf Life
-20°C 3 years powder; -80°C 2 years in solvent
Shipping
Room temperature, or blue ice upon request.
Storage
-20°C
Boiling Point
752.2±60.0 °C at 760 mmHg
Form
Solid

Biotin-PEG2-acid, a versatile bifunctional molecule central to bioconjugation and biotechnology, finds diverse applications. Here are four key uses of Biotin-PEG2-acid presented with high perplexity and burstiness:

Protein Labeling: Employing Biotin-PEG2-acid enables precise protein labeling, facilitating detection and purification via robust streptavidin-biotin interactions. This technique proves invaluable in affinity chromatography, selectively isolating biotinylated proteins from complex mixtures. The PEG2 spacer plays a pivotal role, enhancing solubility and reducing steric hindrance, ultimately optimizing protein binding efficiency and detection accuracy.

Drug Delivery Systems: Enter the realm of targeted drug delivery systems, where Biotin-PEG2-acid emerges as a key player. By conjugating therapeutic agents to biotin, drug compounds can be guided to specific cells or tissues expressing biotin-binding proteins. The PEG2 linker takes the stage, enhancing biocompatibility and circulation time, bolstering the therapeutic efficacy of the conjugated drugs.

Immunoassays: In the realm of immunoassay development, Biotin-PEG2-acid takes center stage in biotinylating antibodies or antigens, employing streptavidin-coated surfaces for detection. This approach finds widespread use in diagnostic assays like ELISAs and western blots, owing to the high affinity and specificity of the biotin-streptavidin interaction. The PEG2 spacer serves as a critical ally, minimizing non-specific binding and elevating assay sensitivity and precision.

Cell Surface Modification: Witness the transformative potential of Biotin-PEG2-acid in cell surface modification through biotinylation of cell membrane proteins. This strategic move allows for precise attachment of streptavidin-conjugated molecules, such as fluorescent probes or nanoparticles, onto the cell surface. This technique unlocks opportunities for cell labeling, tracking, and targeted imaging studies, shedding light on intricate cell behaviors and interactions.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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