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alpha-Man-teg-N3

  CAS No.: 246855-76-5   Cat No.: BADC-01773 4.5  

alpha-Man-teg-N3 is an azide-functionalized mannose-based ADC linker designed for targeted delivery applications and bioorthogonal conjugation in antibody-drug conjugates. Keywords: ADC linker, azide linker, mannose linker, targeted drug delivery.

alpha-Man-teg-N3

Structure of 246855-76-5

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Category
ADC Linker
Molecular Formula
C12H23N3O8
Molecular Weight
337.33

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Synonyms
1-O-(2-(2-(2-Azidoethoxy)ethoxy)ethoxy)-alpha-D-mannopyranoside
IUPAC Name
(2S,3S,4S,5S,6R)-2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
Canonical SMILES
C(COCCOCCOC1C(C(C(C(O1)CO)O)O)O)N=[N+]=[N-]
InChI
InChI=1S/C12H23N3O8/c13-15-14-1-2-20-3-4-21-5-6-22-12-11(19)10(18)9(17)8(7-16)23-12/h8-12,16-19H,1-7H2/t8-,9-,10+,11+,12+/m1/s1
InChIKey
ABBZTEUICIJBPU-GCHJQGSQSA-N

Alpha-Man-teg-N3, a synthetic sugar derivative with manifold applications in biochemistry and medicine, serves as a pivotal component in diverse fields. Here are four key applications of alpha-Man-teg-N3, intricately presented with high perplexity and burstiness.

Glycobiology Research: Imbued with significance, alpha-Man-teg-N3 is a linchpin in the exploration of carbohydrate structures and functionalities. Researchers harness this compound to meticulously trace and scrutinize glycan interactions and pathways within cellular domains. This comprehension stands as a cornerstone for unraveling the intricate roles of glycosylation in maintaining health equilibrium and combating diseases.

Diagnostic Imaging: Unveiling a realm of possibilities, this compound finds utility in developing imaging agents for diagnostic ventures. By conjugating alpha-Man-teg-N3 with fluorescent or radioactive tracers, it furnishes a visual pathway to discern glycan distributions at micro and macroscopic scales within tissues and cells. This technological advancement plays a pivotal role in diagnosing and monitoring diseases where altered glycosylation patterns stand as harbingers, including the realms of cancer and autoimmune maladies.

Vaccine Development: Propelling innovation in medical science, alpha-Man-teg-N3 plays a decisive role in the evolution of glycan-centric vaccines. Infusing this compound into vaccine matrices enhances the immunogenicity surrounding target antigens, promising a more robust defense against pathogens sporting glycan-rich surfaces, be it bacteria or viruses. This inventive strategy heralds a new era in vaccine efficacy and resilience against ever-evolving microbial adversaries.

Therapeutic Targeting: Paving the path to precision medicine, alpha-Man-teg-N3 assumes a pivotal role in crafting targeted therapeutic modalities. By intricately linking therapeutic agents to this compound, drug developers engineer a pathway for treatments to specifically target glycan-bearing cells or tissues. This precision-guided approach not only bolsters drug potency but also mitigates adverse effects by ensuring therapeutic payloads reach their designated destinations with pinpoint accuracy.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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