Deruxtecan analog is a drug-linker conjugate for antibody-drug conjugate (ADC). Deruxtecan, a topoisomerase I inhibitor, is an exatecan derivative (DX-8951 derivative) with a cleavable pepetide linker and a maleimide group. The maleimide group in Deruxtecan can react with antibody to form antibody-drug conguates (ADC) such as Trastuzumab deruxtecan (DS-8201a), which is a HER2-targeting antibody-drug conjugate. DS-8201a significantly suppressed tumor growth in an immunocompetent mouse model with human HER2-expressing CT26.WT (CT26.WThHER2) cells. DS-8201a is currently in clinical trials.
Catalog Number | Size | Price | Quantity |
---|---|---|---|
BADC-00606 | 5 mg | $649 |
NCT Number | Condition Or Disease | Phase | Start Date | Sponsor | Status |
---|---|---|---|---|---|
NCT04526691 | Advanced or Metastatic NSCLC | Phase 1 | 2021-10-22 | Daiichi Sankyo, Inc. | Recruiting |
NCT04965766 | Metastatic Breast Cancer | Phase 2 | 2021-07-16 | Gustave Roussy, Cancer Campus, Grand Paris | Recruiting |
NCT05113251 | Breast Neoplasms | Phase 3 | 2021-11-09 | AstraZeneca | Recruiting |
NCT04619004 | Non-Small Cell Lung Cancer Metastatic | Phase 2 | 2021-11-15 | Daiichi Sankyo, Inc. | Recruiting |
NCT04622319 | HER2-Positive Primary Breast Cancer | Phase 3 | 2021-11-05 | Daiichi Sankyo, Inc. | Recruiting |
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.