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Fmoc-PEG4-NHS ester is a PEG derivative containing an Fmoc-protected amine and an NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic conditions to obtain the free amine which can be used for further conjugations. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-00582 | -- | $-- | Inquiry |
Fmoc-PEG4-NHS ester, a versatile reagent in the realm of bioconjugation and peptide synthesis, offers enhanced solubility and stability. Here are four key applications of Fmoc-PEG4-NHS ester:
Peptide Synthesis: Serving as a linchpin in solid-phase peptide synthesis, Fmoc-PEG4-NHS ester emerges as a critical linker facilitating the introduction of polyethylene glycol (PEG) spacers. These PEG spacers not only amplify the solubility of peptides but also streamline their handling and purification processes. The true brilliance of this reagent shines through when synthesizing lengthy or hydrophobic peptides, which present challenges in aqueous environments owing to their inherent properties.
Protein Labeling: In protein science, Fmoc-PEG4-NHS ester empowers the efficient labeling of proteins with PEG chains, thereby enhancing their solubility and stability. Such modifications play a foundational role in the realm of protein-based therapeutics, as PEGylation can effectively dampen immunogenic responses and prolong the half-life of proteins in vivo. These enhancements catalyze the efficacy and longevity of protein drugs in clinical settings.
Bioconjugation: In bioconjugation chemistry, Fmoc-PEG4-NHS ester emerges as a versatile linker for attaching small molecules, fluorophores, or drugs to biomolecules such as antibodies or enzymes. The PEG component deftly minimizes steric hindrance and enhances solubility, ensuring optimal performance of bioconjugates. This methodology plays a pivotal role in sculpting precision-targeted therapies, diagnostics, and cutting-edge biosensors.
Surface Modification: Spearheading advancements in biomaterial engineering, Fmoc-PEG4-NHS ester plays a pivotal role in customizing the surfaces of biomaterials and medical devices to imbue hydrophilicity and curb nonspecific protein adsorption. By conjugating PEG chains to surfaces, the biocompatibility and functionality of implants, drug delivery systems, and diagnostic tools undergo a profound enhancement.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
