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Fmoc-PEG4-GGFG-CH2-O-CH2-Cbz is a cleavable ADC linker containing 4 units of PEG.
| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-01801 | -- | $-- | Inquiry |
Fmoc-PEG4-GGFG-CH2-O-CH2-Cbz, a versatile biochemical reagent, finds wide applications in peptide synthesis and drug delivery systems. Here are four key applications:
Peptide Synthesis: Playing a pivotal role in solid-phase peptide synthesis, Fmoc-PEG4-GGFG-CH2-O-CH2-Cbz aids in crafting intricate peptide chains. The Fmoc group acts as a protective shield for the amino terminus, ensuring seamless synthesis. This reagent facilitates the meticulous assembly of peptides, guaranteeing high purity and yield in the final products.
Drug Delivery Systems: Delving into the realm of drug delivery systems, this reagent features prominently in optimizing the solubility and stability of therapeutic agents. The PEG spacer injects hydrophilicity, enhancing the bioavailability of hydrophobic drugs. Featuring a GGFG sequence as a cleavable linker, it artfully unveils the active drug under specific physiological conditions, maximizing therapeutic potential.
Protein Conjugation: In the protein conjugation, Fmoc-PEG4-GGFG-CH2-O-CH2-Cbz steps in to amplify the functionality and therapeutic efficacy of proteins. The PEG spacer acts as a shield against immunogenicity and prolongs the half-life of therapeutic proteins. Conjugating with this reagent promises enhanced pharmacokinetic and pharmacodynamic profiles.
Bioconjugate Chemistry: Diving into bioconjugate chemistry, this reagent offers a gateway to meld various biomolecules like antibodies, enzymes, and nucleic acids with targeting moieties or functional groups. PEGylation, a key feature, mitigates steric hindrance and bolsters overall stability. These bioconjugates facilitate targeted drug delivery and molecular imaging.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
