Name: 5-Maleimidovalericacid-NHS
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Synonyms

2,5-dioxopyrrolidin-1-yl 5-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)pentanoate;

IUPAC Name

(2,5-dioxopyrrolidin-1-yl) 5-(2,5-dioxopyrrol-1-yl)pentanoate

Canonical SMILES

C1CC(=O)N(C1=O)OC(=O)CCCCN2C(=O)C=CC2=O

InChI

InChI=1S/C13H14N2O6/c16-9-4-5-10(17)14(9)8-2-1-3-13(20)21-15-11(18)6-7-12(15)19/h4-5H,1-3,6-8H2

InChIKey

ULZJAHZPCLFGHQ-UHFFFAOYSA-N

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Soild powder

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Room temperature

5-Maleimidovalericacid-NHS (MVA-NHS), a versatile crosslinker reagent, holds a significant presence in bioconjugation and biomolecular research. Here are four key applications of MVA-NHS presented with a high degree of perplexity and burstiness:

Protein-Protein Conjugation: MVA-NHS emerges as a pivotal tool for bridging diverse proteins via their thiol groups, leading to the formation of robust protein conjugates. This technique proves invaluable for crafting antibody-drug conjugates tailored for precise therapies. Leveraging MVA-NHS for conjugation not only ensures the preservation of biological activity in the connected proteins but also enables precise targeting with exceptional specificity.

Enzyme Immobilization: In the realm of biotechnology, MVA-NHS takes center stage for tethering enzymes onto solid supports like beads or columns. This strategic immobilization enhances the efficiency and control of enzymatic reactions, making them more potent. The reusability and improved stability of immobilized enzymes make them indispensable for various industrial applications, showcasing the versatility of MVA-NHS in catalyzing biotechnological advancements.

Diagnostics Development: Assuming a critical role in diagnostic assay development, MVA-NHS plays a pivotal part in linking antibodies to detection molecules such as fluorescent dyes or enzymatic reporters. The resulting conjugates, enabled by MVA-NHS, feature prominently in techniques like ELISA and immunohistochemistry, enabling highly sensitive and specific detection of biomarkers. Integrating MVA-NHS in diagnostics enhances the accuracy and reliability of diagnostic tests, setting new standards in precision and efficacy.

Drug Delivery Systems: The utility of MVA-NHS extends to the realm of drug delivery systems, excelling in linking therapeutic agents to carrier molecules such as polymers or nanoparticles. This innovative approach enables the creation of controlled-release formulations, elevating the pharmacokinetic properties of drugs to new levels. Through the stable and efficient linkage provided by MVA-NHS, the overall efficacy of therapeutic agents is significantly enhanced, ushering in a new era of precision medicine.