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1-Cbz-3-Hydroxyazetidine

  CAS No.: 128117-22-6   Cat No.: BADC-01668 4.5  

1-Cbz-3-Hydroxyazetidine provides a protected cyclic linker moiety for antibody-drug conjugates, enhancing conjugation precision and improving ADC stability and therapeutic index.

1-Cbz-3-Hydroxyazetidine

Structure of 128117-22-6

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ADC Linker
Molecular Formula
C11H13NO3
Molecular Weight
207.23
Shipping
Sealed in dry, 2-8 °C

* For research and manufacturing use only. We do not sell to patients.

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Synonyms
N-cbz-3-hydroxyazetidine; 1-N-Cbz-3-Hydroxyazetidine; 1-benzyloxycarbonyl-3-hydroxyazetidine
IUPAC Name
Benzyl 3-hydroxyazetidine-1-carboxylate
Canonical SMILES
C1C(CN1C(=O)OCC2=CC=CC=C2)O
InChI
InChI=1S/C11H13NO3/c13-10-6-12(7-10)11(14)15-8-9-4-2-1-3-5-9/h1-5,10,13H,6-8H2
InChIKey
XJWSNDGCJMGHSR-UHFFFAOYSA-N
Density
1.3±0.1 g/cm3
Appearance
White powder
Storage
Sealed in dry, 2-8 °C
Signal Word
Warning
Boiling Point
356.7±42.0 °C at 760 mmHg

1-Cbz-3-Hydroxyazetidine, a versatile compound with myriad chemical and pharmaceutical applications, plays a pivotal role in diverse fields. Here are four key applications of 1-Cbz-3-Hydroxyazetidine presented with high perplexity and burstiness:

Pharmaceutical Synthesis: Acting as a crucial intermediary in synthesizing various bioactive molecules and pharmaceutical compounds, 1-Cbz-3-Hydroxyazetidine is fundamental in the creation of azetidinone derivatives essential for drug discovery and development. Its adaptable structure facilitates seamless modifications, fostering the development of a wide array of therapeutic agents.

Organic Chemistry Research: Within the expansive realm of organic chemistry, 1-Cbz-3-Hydroxyazetidine is a frequently utilized component in the synthesis of intricate molecules. Its functional groups make it an invaluable cornerstone for constructing heterocycles and other complex structures, empowering researchers to delve into uncharted territories of organic synthesis through novel chemical reactions and pathways.

Medicinal Chemistry: The world of medicinal chemistry harnesses 1-Cbz-3-Hydroxyazetidine for designing and synthesizing cutting-edge pharmaceuticals. Its distinctive chemical characteristics pave the way for crafting inhibitors, agonists, or modulators targeting various biological entities. By tailoring its structure, scientists can fine-tune the pharmacokinetic and pharmacodynamic properties of potential therapeutic agents to enhance efficacy.

Polymer Chemistry: In the domain of polymer chemistry, 1-Cbz-3-Hydroxyazetidine finds utility as a monomer or comonomer in fabricating specialized polymers. These polymers find applications in drug delivery systems where precise pharmaceutical release mechanisms are paramount. Leveraging its reactivity and compatibility with other monomers, researchers can engineer materials with specific mechanical and chemical attributes to address unique needs in various industries.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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