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1-((4-((2-(2-(7-Amino-4-Methyl-1-Oxo-1H-Isochromen-3-Yl)acetamido)ethyl)disulfanyl)butanoyl)oxy)-2,5-Dioxopyrrolidine-3-Sulfonic Acid

  CAS No.: 1246497-13-1   Cat No.: BADC-00568 4.5  

1-((4-((2-(2-(7-Amino-4-methyl-1-oxo-1H-isochromen-3-yl)acetamido)ethyl)disulfanyl)butanoyl)oxy)-2, 5-dioxopyrrolidine-3-sulfonic acid is a linker for antibody-drug-conjugation (ADC).

1-((4-((2-(2-(7-Amino-4-Methyl-1-Oxo-1H-Isochromen-3-Yl)acetamido)ethyl)disulfanyl)butanoyl)oxy)-2,5-Dioxopyrrolidine-3-Sulfonic Acid

Structure of 1246497-13-1

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ADC Linker
Molecular Formula
C22H25N3O10S3
Molecular Weight
587.64
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Room temperature

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Canonical SMILES
CC1=C(OC(=O)C2=C1C=CC(=C2)N)CC(=O)NCCSSCCCC(=O)ON3C(=O)CC(C3=O)S(=O)(=O)O
InChI
InChI=1S/C22H25N3O10S3/c1-12-14-5-4-13(23)9-15(14)22(30)34-16(12)10-18(26)24-6-8-37-36-7-2-3-20(28)35-25-19(27)11-17(21(25)29)38(31,32)33/h4-5,9,17H,2-3,6-8,10-11,23H2,1H3,(H,24,26)(H,31,32,33)
InChIKey
GPHAKSOVTLYNNR-UHFFFAOYSA-N
Shipping
Room temperature

1-((4-((2-(2-(7-Amino-4-Methyl-1-Oxo-1H-Isochromen-3-Yl)acetamido)ethyl)disulfanyl)butanoyl)oxy)-2,5-Dioxopyrrolidine-3-Sulfonic Acid, a complex compound with specific applications in bioscience and medical research, offers diverse possibilities in the following key areas with a high degree of perplexity and burstiness:

Protein Labeling and Modification: Delving into protein chemistry, this compound facilitates selective labeling and modification of proteins by targeting cysteine residues. It empowers the conjugation of fluorescent dyes or other functional groups to proteins, aiding in the exploration of protein structure and function. Employed in various biochemical assays and imaging techniques, this method offers invaluable insights into the intricacies of protein behavior.

Drug Delivery Systems: Boasting a unique chemical structure, this compound finds its niche in targeted drug delivery systems. By conjugating therapeutic agents to this compound, researchers engineer delivery mechanisms that precisely release drugs at the designated site of action. This targeted delivery strategy minimizes unwanted side effects and amplifies the efficacy of treatments, heralding a new era in personalized medicine.

Bioconjugation Chemistry: Serving as a pivotal reagent in bioconjugation reactions, this compound facilitates the formation of stable linkages between biomolecules—a cornerstone in biotechnology advancements. It plays a vital role in crafting antibody-drug conjugates (ADCs) for cancer therapy, seamlessly attaching cytotoxic drugs to antibodies. This innovative approach enhances the selectivity and potency of cancer treatments, offering hope in the fight against this formidable disease.

Enzyme Inhibition Studies: Researchers harness the power of this compound to delve into enzyme mechanisms and inhibition, unraveling the mysteries of enzymatic activity. Through the strategic modification of key amino acids in enzymes, scientists probe the enzyme's active site and study how inhibitors impact its function. This indispensable information guides the design of novel enzyme inhibitors with potential therapeutic applications, shedding light on new pathways in drug development.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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