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1-(4-((5-nitropyridin-2-yl)disulfanyl)pentanoyloxy)-2,5-ioxopyrrolidine-3-sulfonic acid

  CAS No.: 663598-66-1   Cat No.: BADC-00472   Purity: ≥98% 4.5  

1-(4-((5-nitropyridin-2-yl)disulfanyl)pentanoyloxy)-2,5-dioxopyrrolidine-3-sulfonic acid is a cleavable ADC linker facilitating antibody conjugation via NHS sulfonic acid and disulfide bonds, ensuring controlled payload release in tumor cells and enhanced ADC specificity and potency.

1-(4-((5-nitropyridin-2-yl)disulfanyl)pentanoyloxy)-2,5-ioxopyrrolidine-3-sulfonic acid

Structure of 663598-66-1

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Category
ADC Linker
Molecular Formula
C14H15N3O9S3
Molecular Weight
465.48
Shipping
Room temperature, or blue ice upon request.

* For research and manufacturing use only. We do not sell to patients.

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Synonyms
1-[4-[(5-nitropyridin-2-yl)disulfanyl]pentanoyloxy]-2,5-dioxopyrrolidine-3-sulfonic acid;
IUPAC Name
Canonical SMILES
CC(CCC(=O)ON1C(=O)CC(C1=O)S(=O)(=O)O)SSC2=NC=C(C=C2)[N+](=O)[O-]
InChI
InChI=1S/C14H15N3O9S3/c1-8(27-28-11-4-3-9(7-15-11)17(21)22)2-5-13(19)26-16-12(18)6-10(14(16)20)29(23,24)25/h3-4,7-8,10H,2,5-6H2,1H3,(H,23,24,25)
InChIKey
YIZUQMMWCFGOAA-UHFFFAOYSA-N
Appearance
Soild powder
Shipping
Room temperature, or blue ice upon request.

1-(4-((5-nitropyridin-2-yl)disulfanyl)pentanoyloxy)-2,5-ioxopyrrolidine-3-sulfonic acid is a complex chemical compound with potential applications in bioscience and pharmaceutical research. Here are some key applications:

Bioconjugation: This compound can be utilized in bioconjugation techniques to link biomolecules like proteins, peptides, or antibodies. By using its functional groups, it allows for specific and stable attachment to target molecules. This application is essential in the development of targeted drug delivery systems and diagnostic assays.

Protein Labeling: The unique chemical structure of 1-(4-((5-nitropyridin-2-yl)disulfanyl)pentanoyloxy)-2,5-ioxopyrrolidine-3-sulfonic acid makes it suitable for labeling proteins with fluorescent or radioactive tags. This facilitates the tracking and quantification of proteins in various biological experiments. Such labeled proteins are vital in research areas like proteomics and molecular biology.

Redox Studies: Due to the presence of the disulfide bond, this compound is ideal for redox biology studies focusing on the function and regulation of redox-active enzymes and pathways. Researchers can use it to investigate redox mechanisms and their role in cellular physiology. Its application can help in understanding oxidative stress and developing antioxidants.

Enzyme Inhibition Studies: This compound has potential use as an enzyme inhibitor, especially for enzymes involved in sulfur metabolism and oxidation-reduction (redox) reactions. By studying its interaction with specific enzymes, scientists can gain insights into enzyme functions and regulatory mechanisms. This information is crucial for the development of new therapeutic agents targeting these enzymes.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Historical Records: DM4-SPDB | S-Me-DM4 | Deruxtecan | 1-(4-methyl-4-(pyridin-2-yldisulfanyl)pentanoyloxy)-2,5-dioxopyrrolidine-3-sulfonic acid | 1-((4-((2-(2-(7-Amino-4-Methyl-1-Oxo-1H-Isochromen-3-Yl)acetamido)ethyl)disulfanyl)butanoyl)oxy)-2,5-Dioxopyrrolidine-3-Sulfonic Acid | Azido-PEG9-amine | Biotin-PEG2-acid | Tesirine | MMAF-OMe | 1-((1r,4r)-4-((2,5-dioxo-2H-pyrrol-1(5H)-yl)methyl)cyclohexanecarbonyloxy)-2,5-dioxopyrrolidine-3-sulfonic acid | 1-(4-((5-nitropyridin-2-yl)disulfanyl)pentanoyloxy)-2,5-ioxopyrrolidine-3-sulfonic acid
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