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N-[gamma-Maleimidobutyryloxy]sulfo-succinimide ester is a highly significant and versatile compound that plays a pivotal role in the realm of biomedicine. Specifically designed for the purpose of labeling and conjugating biomolecules, this remarkable product has garnered immense attention in the field. Its wide-ranging applications span the development of targeted therapies, imaging agents, and drug delivery systems. By virtue of its maleimide group, which exhibits exceptional specificity, it empowers researchers to precisely target sulfhydryl-containing proteins or antibodies, thereby rendering feasible the treatment of an array of diseases, including but not limited to cancer or autoimmune disorders.
![N-[gamma-Maleimidobutyryloxy]sulfo-succinimide ester](https://resource.bocsci.com/structure/158018-81-6.gif)
| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-00368 | -- | $-- | Inquiry |
N-[gamma-Maleimidobutyryloxy]sulfo-succinimide ester, commonly known as sulfo-GMBS, is a versatile cross-linking reagent widely utilized in bioconjugation endeavors. Here, we explore four key applications of N-[gamma-Maleimidobutyryloxy]sulfo-succinimide ester:
Protein Conjugation: Within the realm of protein conjugation, sulfo-GMBS shines as a go-to choice for linking sulfhydryl groups to primary amines. This trait is particularly advantageous in the domain of antibody labeling, where the modification of one molecule with a maleimide group enables steadfast attachment to another molecule housing free thiol groups.
Immobilization of Biomolecules: Leveraging its cross-linking capabilities, sulfo-GMBS finds applications in the effective immobilization of enzymes, antibodies, or other proteins onto solid supports like beads or microplate surfaces. By forging covalent bonds between biomolecules and surfaces, sulfo-GMBS elevates the stability and reusability of biosensors and diagnostic assays.
Development of Proteomics Tools: In the dynamic field of proteomics, sulfo-GMBS emerges as a pivotal tool for unraveling protein interactions by cross-linking interacting partners within complex molecular frameworks. This innovative approach aids in pinpointing and stabilizing transient or weak interactions that elude conventional detection methods.
Surface Modification: A catalyst for surface modification, sulfo-GMBS imparts surfaces with reactive maleimide groups that engage seamlessly with thiol-containing molecules, propelling advancements in biotechnology applications. This transformative capability empowers the enhancement of material surfaces to bolster biocompatibility and functionalization for tailored applications. These modified surfaces find diverse applications in realms such as tissue engineering, biomaterials development, and designing innovative drug delivery systems, underscoring the versatility of sulfo-GMBS in driving progressive bioengineering solutions.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
