1-(4-((5-nitropyridin-2-yl)disulfanyl)butanoyloxy)-2,5-dioxopyrrolidine-3-sulfonic acid is an ADC linker containing cleavable disulfide bonds and NHS ester functionalities, facilitating stable antibody conjugation and tumor-specific payload release for enhanced ADC selectivity and cytotoxicity.
Structure of 663598-89-8
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Capabilities & Facilities
1-(4-((5-nitropyridin-2-yl)disulfanyl)butanoyloxy)-2,5-dioxopyrrolidine-3-sulfonic acid is a chemical compound with specialized applications in biochemical research and industrial processes. Here are some key applications of this compound:
Protein Labeling and Modification: This compound can be used to label and modify proteins through the disulfide bond. By attaching this molecule to specific cysteine residues on proteins, researchers can change the protein's functionality or track its location in cellular studies. This technique is vital for understanding protein dynamics and interactions.
Enzyme Inhibition Studies: This compound can act as an inhibitor for certain enzymes that interact with disulfide bonds or similar structures. By studying the inhibition effects of this molecule, scientists can gain insights into enzyme mechanisms and identify potential drug targets. This is crucial for the development of therapeutic agents against diseases involving these enzymes.
Redox Biology and Chemistry: The disulfide bond in this compound makes it useful for studies in redox biology, where the focus is on the oxidative and reductive processes in cells. Researchers can use it to probe redox-sensitive elements within biological systems. This enables the investigation of cellular stress responses and the development of antioxidant therapies.
Drug Delivery Systems: This compound can be incorporated into drug delivery systems that require precise release mechanisms. The disulfide bond can be selectively cleaved in reductive environments, allowing for targeted release of therapeutics within specific cellular compartments. This targeted approach enhances the efficacy and safety of drug delivery.
Catalog | Product Name | CAS | Inquiry |
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BADC-00568 | 1-((4-((2-(2-(7-Amino-4-Methyl-1-Oxo-1H-Isochromen-3-Yl)acetamido)ethyl)disulfanyl)butanoyl)oxy)-2,5-Dioxopyrrolidine-3-Sulfonic Acid | 1246497-13-1 | |
BADC-00455 | 1-((1r,4r)-4-((2,5-dioxo-2H-pyrrol-1(5H)-yl)methyl)cyclohexanecarbonyloxy)-2,5-dioxopyrrolidine-3-sulfonic acid | 1286837-77-1 | |
BADC-00472 | 1-(4-((5-nitropyridin-2-yl)disulfanyl)pentanoyloxy)-2,5-ioxopyrrolidine-3-sulfonic acid | 663598-66-1 | |
BADC-00465 | 1-(4-methyl-4-((5-nitropyridin-2-yl)disulfanyl)pentanoyloxy)-2,5-dioxopyrrolidine-3-sulfonic acid | 663599-00-6 | |
BADC-00478 | 1-(4-((5-(dimethylcarbamoyl)pyridin-2-yl)disulfanyl)butanoyloxy)-2,5-dioxopyrrolidine-3-sulfonic acid | 663599-07-3 | |
BADC-00469 | 1-(4-((3-(dimethylcarbamoyl)pyridin-4-yl)disulfanyl)pentanoyloxy)-2,5-dioxopyrrolidine-3-sulfonic acid | 663599-11-9 | |
BADC-00467 | 1-(4-methyl-4-(pyridin-2-yldisulfanyl)pentanoyloxy)-2,5-dioxopyrrolidine-3-sulfonic acid |
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