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CAS No.: 663598-89-8
Cat No.: BADC-00479
Purity: ≥98%
4.5 
1-(4-((5-nitropyridin-2-yl)disulfanyl)butanoyloxy)-2,5-dioxopyrrolidine-3-sulfonic acid is a disulfide-containing crosslinker or linker building block for redox-responsive bioconjugation and ADC-related linker design. The disulfide bond provides a reduction-sensitive element, while the terminal reactive groups enable attachment to appropriately functionalized biomolecules or small-molecule partners. The molecule uses nhs/succinimidyl ester (amine-reactive) for antibody lysines/primary amines (common orientation) on one side and pyridyl-disulfide / activated disulfide handle for thiol-containing payloads or thiol exchange partners on the other, with disulfide trigger with c4/alkyl spacer segment providing the spacer/cleavable region. Conjugation orientation and reduction sensitivity should be evaluated in the context of the final construct because local substitution and neighboring groups can influence disulfide behavior.
Structure of 663598-89-8
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1-(4-((5-nitropyridin-2-yl)disulfanyl)butanoyloxy)-2,5-dioxopyrrolidine-3-sulfonic acid is a chemical compound with specialized applications in biochemical research and industrial processes. Here are some key applications of this compound:
Protein Labeling and Modification: This compound can be used to label and modify proteins through the disulfide bond. By attaching this molecule to specific cysteine residues on proteins, researchers can change the protein's functionality or track its location in cellular studies. This technique is vital for understanding protein dynamics and interactions.
Enzyme Inhibition Studies: This compound can act as an inhibitor for certain enzymes that interact with disulfide bonds or similar structures. By studying the inhibition effects of this molecule, scientists can gain insights into enzyme mechanisms and identify potential drug targets. This is crucial for the development of therapeutic agents against diseases involving these enzymes.
Redox Biology and Chemistry: The disulfide bond in this compound makes it useful for studies in redox biology, where the focus is on the oxidative and reductive processes in cells. Researchers can use it to probe redox-sensitive elements within biological systems. This enables the investigation of cellular stress responses and the development of antioxidant therapies.
Drug Delivery Systems: This compound can be incorporated into drug delivery systems that require precise release mechanisms. The disulfide bond can be selectively cleaved in reductive environments, allowing for targeted release of therapeutics within specific cellular compartments. This targeted approach enhances the efficacy and safety of drug delivery.
1-(4-((5-nitropyridin-2-yl)disulfanyl)butanoyloxy)-2,5-dioxopyrrolidine-3-sulfonic acid
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1-(4-((5-nitropyridin-2-yl)disulfanyl)butanoyloxy)-2,5-dioxopyrrolidine-3-sulfonic acid
Required fields are marked with *
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