Name: Mal-DPEG4-NHS
Brand: BOC Sciences
Rating: 5 (1 reviews)

Synonyms

2,5-dioxopyrrolidin-1-yl 19-(2,5-dioxo-2H-pyrrol-1(5H)-yl)-17-oxo-4,7,10,13-tetraoxa-16-azanonadecan-1-oate;

IUPAC Name

(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]propanoate

Canonical SMILES

C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCOCCNC(=O)CCN2C(=O)C=CC2=O

InChI

InChI=1S/C22H31N3O11/c26-17(5-8-24-18(27)1-2-19(24)28)23-7-10-33-12-14-35-16-15-34-13-11-32-9-6-22(31)36-25-20(29)3-4-21(25)30/h1-2H,3-16H2,(H,23,26)

InChIKey

XSRYGQJQNPJNKZ-UHFFFAOYSA-N

Appearance

Soild powder

Shipping

Room temperature, or blue ice upon request.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Mal-DPEG4-NHS, a versatile bifunctional crosslinker, finds extensive utility in bioconjugation and bioengineering.

Protein Conjugation: Mal-DPEG4-NHS emerges as a pivotal tool for linking proteins and peptides. Through its NHS ester group’s targeted reaction with primary amines, this compound facilitates the binding of biomolecules like antibodies to a spectrum of surfaces or molecules, amplifying their functionality. The resultant conjugates, whether utilized in assays, imaging, or therapeutics, offer a flexible solution for both research and industrial domains.

Drug Delivery Systems: Transitioning to the field of drug delivery, Mal-DPEG4-NHS assumes a crucial role as a linking agent for attaching therapeutic compounds to specialized delivery systems like nanoparticles or liposomes. By establishing robust covalent bonds, it ensures the precise transport of drugs to specific cells or tissues, optimizing drug effectiveness, mitigating side effects, and ultimately enhancing patient outcomes through targeted delivery strategies.

Surface Modification: Within the context of surface modification, Mal-DPEG4-NHS takes center stage in enhancing the biocompatibility of biomaterial surfaces or introducing functional groups for subsequent reactions. This application holds particular significance in the development of biomedical devices, where surface enhancements play a key role in reducing immune reactions and enhancing device integration. Tailored modifications cater to diverse applications in areas such as tissue engineering, implants, and diagnostics.

Bioimaging: Mal-DPEG4-NHS unfolds its potential in conjugating fluorescent dyes or imaging agents to biomolecules, allowing for their visualization within cellular or tissue environments. This functionality is pivotal in tracking biological processes, diagnosing diseases, or monitoring the effectiveness of therapeutic interventions.