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Amino-PEG2-C2-acid is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-01160 | -- | $-- | Inquiry |
Amino-PEG2-propionic acid is widely utilized in drug delivery systems due to its ability to enhance the solubility and stability of drugs. Its PEG (polyethylene glycol) linker segment allows for increased hydrophilicity, thereby improving the drug’s bioavailability and prolonging its circulation time in the bloodstream. This polymeric component is also flexible and biocompatible, reducing the potential for adverse immune responses. As a result, it facilitates the effective targeting and sustained release of therapeutic agents, making it a crucial component in the design of advanced drug delivery vehicles.
Another significant application of Amino-PEG2-propionic acid lies in bioconjugation, where it serves as a linker molecule for attaching various biomolecules. The amino group allows for covalent bonding with carboxyl groups on proteins, peptides, or other biomolecules, while the PEG chain provides the necessary flexibility and distance to minimize steric hindrance. This is especially valuable in the development of antibody-drug conjugates (ADCs), where the compound enables the attachment of cytotoxic drugs to antibodies, thereby facilitating targeted cancer therapy.
Amino-PEG2-propionic acid also plays a pivotal role in surface modification, particularly for biomedical implants and devices. By grafting this compound onto surfaces, it is possible to enhance the biocompatibility and reduce the nonspecific binding of proteins and cells. This PEGylation technique creates a hydrophilic barrier on the surface, which can significantly improve the performance and longevity of medical implants such as stents, catheters, and prosthetics. This surface modification is crucial for reducing thrombus formation and improving the overall integration of implants within the body.
Finally, in the field of diagnostics, Amino-PEG2-propionic acid is an essential component in the development of sensor technologies. The PEG spacer can be used to strategically position recognition elements such as antibodies or nucleic acids on the surface of biosensors. This spatial arrangement enhances the sensor’s sensitivity and specificity by ensuring optimal interaction with target analytes. Consequently, biosensors incorporating Amino-PEG2-propionic acid linkers are employed in a variety of diagnostic applications, including the detection of pathogens, biomarkers, and environmental contaminants.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
