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Amino-PEG4-propionic acid

  CAS No.: 663921-15-1   Cat No.: BADC-01144   Purity: > 98.0 % 4.5  

Amino-PEG4-propionic acid is a medium-length PEG linker intermediate designed to improve antibody solubility and conjugation stability in ADCs. It enhances drug loading efficiency and supports controlled payload release for targeted therapies.

Amino-PEG4-propionic acid

Structure of 663921-15-1

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Category
ADC Linker
Molecular Formula
C11H23NO6
Molecular Weight
265.30
Shipping
Room temperature, or blue ice upon request.
Shipping
-20 °C

* For research and manufacturing use only. We do not sell to patients.

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Popular Publications Citing BOC Sciences Products
Synonyms
1-Amino-3,6,9,12-tetraoxapentadecan-15-oic acid; Amino-PEG4-acid; (PEO)4-amino-propionic acid
IUPAC Name
3-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]propanoic acid
Canonical SMILES
C(COCCOCCOCCOCCN)C(=O)O
InChI
InChI=1S/C11H23NO6/c12-2-4-16-6-8-18-10-9-17-7-5-15-3-1-11(13)14/h1-10,12H2,(H,13,14)
InChIKey
DKUZHSDZSMQOGQ-UHFFFAOYSA-N
Density
1.1±0.1 g/cm3
Solubility
10 mm in DMSO
Flash Point
201.5±27.3 °C
Index Of Refraction
1.469
PSA
100.24000
Vapor Pressure
0.0±2.1 mmHg at 25°C
Appearance
Solid
Shipping
Room temperature, or blue ice upon request.
Storage
-20 °C
Pictograms
Irritant
Signal Word
Warning
Boiling Point
409.6±40.0 °C at 760 mmHg
Form
Solid

Amino-PEG4-propionic acid, a versatile reagent, finds application in diverse chemical and biological realms. Explore its key applications with a twist of high perplexity and burstiness:

Bioconjugation: Engage in bioconjugation marvels leveraging Amino-PEG4-propionic acid, a stellar performer in linking biomolecules like proteins or peptides with entities such as fluorophores or therapeutic marvels. The PEG4 spacer, introducing flexibility and mitigating steric hindrances, elevates the stability and functionality of the resulting conjugate. Witness this prowess in crafting cutting-edge diagnostic tools and precision-driven drug delivery conduits.

Drug Delivery: Enter the realm of drug delivery where Amino-PEG4-propionic acid shines in tailoring nanoparticle surfaces towards enhanced biocompatibility and circulation longevity. By embedding this reagent onto drug-laden nanoparticles, scientists unlock superior targeting precision and evade swift immune clearance. Embrace heightened therapeutic efficacy and diminished adverse effects in the realm of drug dispensation.

Polymer Chemistry: Unfold the potential of Amino-PEG4-propionic acid as a linchpin in crafting functionalized polymers essential for hydrogels, biocompatible coatings, and stimuli-responsive materials. The amino group's facile integration with diverse polymer frameworks, coupled with the PEG spacer's proffered hydrophilicity and suppleness, births materials boasting custom properties tailored for medical and industrial arenas.

Surface Modification: Dive into the widespread use of this compound in augmenting biomaterial surfaces to optimize their interaction with biological milieus. Witness how Amino-PEG4-propionic acid adorns implant surfaces, curbing protein adhesion and platelet interactions to elevate biocompatibility. Such modifications stand as pivotal milestones in the evolution of medical implements and the creation of tissue engineering masterpieces.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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