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t-Boc-N-amido-PEG4-propionic acid

  CAS No.: 756525-91-4   Cat No.: BADC-01151   Purity: ≥95% 4.5  

Boc-NH-PEG4-CH2CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC. Boc-NH-PEG4-CH2CH2COOH is also a cleavable ADC linker used as a linker for antibody-drug conjugates (ADC).

t-Boc-N-amido-PEG4-propionic acid

Structure of 756525-91-4

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Category
ADC Linker
Molecular Formula
C16H31NO8
Molecular Weight
365.42
Shipping
Room temperature, or blue ice upon request.
Shipping
Store at 2-8°C

* For research and manufacturing use only. We do not sell to patients.

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Popular Publications Citing BOC Sciences Products
Synonyms
t-Boc-N-amido-PEG4-acid; 15-(Boc-amino)-4,7,10,13-tetraoxapentadecanoic acid; 2,2-Dimethyl-4-oxo-3,8,11,14,17-pentaoxa-5-azaicosan-20-oic acid; (Boc-amino)-PEG4-carboxylic Acid; Boc-NH-PEG4-CH2CH2COOH; t-Boc-NH-amido-PEG4-COOH; Boc-NH-PEG4-COOH; N-(tert-Butyloxycarbonyl)-15-amino-4,7,10,13-tetraoxapentanedecanoic Acid; 5,8,11,14-Tetraoxa-2-azaheptadecanedioic acid, 1-(1,1-dimethylethyl) ester
IUPAC Name
3-[2-[2-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
Canonical SMILES
CC(C)(C)OC(=O)NCCOCCOCCOCCOCCC(=O)O
InChI
InChI=1S/C16H31NO8/c1-16(2,3)25-15(20)17-5-7-22-9-11-24-13-12-23-10-8-21-6-4-14(18)19/h4-13H2,1-3H3,(H,17,20)(H,18,19)
InChIKey
YEIYIPDFZMLJQH-UHFFFAOYSA-N
Density
1.124±0.06 g/cm3 at 20°C, 760 Torr
Solubility
Soluble in DMSO (10 mm)
Flash Point
258.9±30.1 °C
Index Of Refraction
1.466
PSA
112.55000
Vapor Pressure
0.0±2.8 mmHg at 25°C
Appearance
Pale Yellow or Colorless Oily Matter
Shipping
Room temperature, or blue ice upon request.
Storage
Store at 2-8°C
Boiling Point
504.5±50.0 °C at 760 mmHg
Form
Liquid
Biological Activity
Boc-NH-PEG4-CH2CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC[1]. Boc-NH-PEG4- CH2CH2COOH is also a cleavable ADC linker used as a linker for antibody-drug conjugates (ADC)[2] . In Vitro: PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADC linker used in the synthesis of antibody-drug conjugates (ADCs)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Historical Records: t-Boc-N-amido-PEG1-propionic acid | t-Boc-N-amido-PEG2-bromide | t-Boc-N-amido-PEG4-propionic acid
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