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t-Boc-N-amido-PEG4-bromide

  CAS No.: 1076199-21-7   Cat No.: BADC-00887   Purity: ≥97.0% 4.5  

t-Boc-N-amido-PEG3-bromide is a PEG linker containing a bromide group and a Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The Boc group can be deprotected under mild acidic conditions to form the free amine.

t-Boc-N-amido-PEG4-bromide

Structure of 1076199-21-7

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Category
ADC Linker
Molecular Formula
C13H26BrNO5
Molecular Weight
356.25
Shipping
Room temperature
Shipping
Store at 2-8°C under inert atmosphere

* For research and manufacturing use only. We do not sell to patients.

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Popular Publications Citing BOC Sciences Products
Synonyms
Br-PEG3-NHBoc; Boc-NH-PEG3-Br; BocNH-PEG3-CH2CH2Br; N-Boc-PEG3-bromide; tert-Butyl (2-(2-(2-(2-bromoethoxy)ethoxy)ethoxy)ethyl)carbamate; 1-Boc-amino-3,6,9-trioxaundecanyl-11-bromide; 2-{2-[2-(2-Boc-aminoethoxy)ethoxy]ethoxy}ethyl Bromide; 13-Bromo-5,8,11-trioxa-2-azatridecanoic Acid 1,1-Dimethylethyl Ester; 2-Methyl-2-propanyl (2-{2-[2-(2-bromoethoxy)ethoxy]ethoxy}ethyl)carbamate; Carbamic acid, N-[2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]ethyl]-, 1,1-dimethylethyl ester
IUPAC Name
tert-butyl N-[2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]ethyl]carbamate
Canonical SMILES
CC(C)(C)OC(=O)NCCOCCOCCOCCBr
InChI
InChI=1S/C13H26BrNO5/c1-13(2,3)20-12(16)15-5-7-18-9-11-19-10-8-17-6-4-14/h4-11H2,1-3H3,(H,15,16)
InChIKey
GNDQONYTPMGMTM-UHFFFAOYSA-N
Density
1.238±0.1 g/cm3
Solubility
Soluble in Chloroform (Slightly), Methanol (Slightly)
PSA
69.51000
Appearance
Pale Yellow or Colorless Oily Matter
Quantity
Data not available, please inquire.
Shelf Life
0-4°C for short term (days to weeks), or -20°C for long term (months).
Shipping
Room temperature
Storage
Store at 2-8°C under inert atmosphere
Boiling Point
422.08 °C at 760 mmHg (Predicted)
Form
Liquid
Biological Activity
N-Boc-PEG4-bromide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1] . In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Historical Records: t-Boc-N-amido-PEG1-propionic acid | t-Boc-N-amido-PEG2-bromide | t-Boc-N-amido-PEG4-propionic acid | t-Boc-N-amido-PEG4-bromide
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