Acetylene-linker-Val-Cit-PABC-MMAE - CAS 1411977-95-1

Acetylene-linker-Val-Cit-PABC-MMAE - CAS 1411977-95-1 Catalog number: BADC-00849

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Acetylene-linker-Val-Cit-PABC-MMAE consists the ADCs linker (Acetylene-linker-Val-Cit-PABC) and potent tubulin inhibitor (MMAE), Acetylene-linker-Val-Cit-PABC-MMAE is an antibody drug conjugate.

Category
ADCs Cytotoxin with Linkers
Product Name
Acetylene-linker-Val-Cit-PABC-MMAE
CAS
1411977-95-1
Catalog Number
BADC-00849
Molecular Formula
C67H106N10O16
Molecular Weight
1307.62
Acetylene-linker-Val-Cit-PABC-MMAE

Ordering Information

Catalog Number Size Price Quantity
BADC-00849 -- $--
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Description
Acetylene-linker-Val-Cit-PABC-MMAE consists the ADCs linker (Acetylene-linker-Val-Cit-PABC) and potent tubulin inhibitor (MMAE), Acetylene-linker-Val-Cit-PABC-MMAE is an antibody drug conjugate.
Synonyms
LCB14-0602
IUPAC Name
[4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-3-methyl-2-[[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]acetyl]amino]butanoyl]amino]pentanoyl]amino]phenyl]methyl N-[(2S)-1-[[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-N-methylcarbamate
Canonical SMILES
O=C([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(COCCOCCOCC#C)=O)=O)NC1=CC=C(COC(N(C)[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N([C@H]([C@@H](CC(N2[C@H]([C@H](OC)[C@H](C(N[C@@H]([C@@H](O)C3=CC=CC=C3)C)=O)C)CCC2)=O)OC)[C@@H](C)CC)C)=O)=O)=O)C=C1
InChI
1S/C67H106N10O16/c1-16-33-90-34-35-91-36-37-92-40-53(78)73-55(41(3)4)63(83)72-50(25-21-31-69-66(68)86)62(82)71-49-29-27-47(28-30-49)39-93-67(87)76(13)57(43(7)8)64(84)74-56(42(5)6)65(85)75(12)58(44(9)17-2)52(88-14)38-54(79)77-32-22-26-51(77)60(89-15)45(10)
InChIKey
HJNJEHBZUVWTEJ-MKXMLHHLSA-N
Density
1.177±0.06 g/cm3
Solubility
10 mm in DMSO
Flash Point
747.3±34.3 °C
Index Of Refraction
1.544
LogP
5.33
Vapor Pressure
0.0±0.3 mmHg at 25°C
Biological Activity
Acetylene-linker-Val-Cit-PABC-MMAE (LCB14-0602) consists the ADCs linker (Acetylene-linker-Val-Cit-PABC) and potent tubulin inhibitor (MMAE). Acetylene-linker-Val-Cit-PABC-MMAE (LCB14-0602) is a drug-linker conjugate for ADC
Appearance
Colorless transparent liquid
Purity
>98.0%
Quantity
Grams-Kilos
Shelf Life
-20℃ 3 years powder; -80℃ 2 years in solvent
Shipping
-20°C (International: -20°C)
Storage
-20°C
Boiling Point
1312.0±65.0 °C | Condition: Press: 760 Torr

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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