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Acetylene-linker-Val-Cit-PABC-MMAE

  CAS No.: 1411977-95-1   Cat No.: BADC-00849   Purity: >98.0% 4.5  

Acetylene-linker-Val-Cit-PABC-MMAE consists the ADCs linker (Acetylene-linker-Val-Cit-PABC) and potent tubulin inhibitor (MMAE), Acetylene-linker-Val-Cit-PABC-MMAE is an antibody drug conjugate.

Acetylene-linker-Val-Cit-PABC-MMAE

Structure of 1411977-95-1

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Category
ADC Cytotoxin with Linker
Molecular Formula
C67H106N10O16
Molecular Weight
1307.62
Shipping
-20°C (International: -20°C)
Shipping
-20°C

* For research and manufacturing use only. We do not sell to patients.

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Synonyms
LCB14-0602
IUPAC Name
[4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-3-methyl-2-[[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]acetyl]amino]butanoyl]amino]pentanoyl]amino]phenyl]methyl N-[(2S)-1-[[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-N-methylcarbamate
Canonical SMILES
O=C([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(COCCOCCOCC#C)=O)=O)NC1=CC=C(COC(N(C)[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N([C@H]([C@@H](CC(N2[C@H]([C@H](OC)[C@H](C(N[C@@H]([C@@H](O)C3=CC=CC=C3)C)=O)C)CCC2)=O)OC)[C@@H](C)CC)C)=O)=O)=O)C=C1
InChI
1S/C67H106N10O16/c1-16-33-90-34-35-91-36-37-92-40-53(78)73-55(41(3)4)63(83)72-50(25-21-31-69-66(68)86)62(82)71-49-29-27-47(28-30-49)39-93-67(87)76(13)57(43(7)8)64(84)74-56(42(5)6)65(85)75(12)58(44(9)17-2)52(88-14)38-54(79)77-32-22-26-51(77)60(89-15)45(10)
InChIKey
HJNJEHBZUVWTEJ-MKXMLHHLSA-N
Density
1.177±0.06 g/cm3
Solubility
10 mm in DMSO
Flash Point
747.3±34.3 °C
Index Of Refraction
1.544
Vapor Pressure
0.0±0.3 mmHg at 25°C
Appearance
Colorless transparent liquid
Quantity
Grams-Kilos
Shelf Life
-20°C 3 years powder; -80°C 2 years in solvent
Shipping
-20°C (International: -20°C)
Storage
-20°C
Boiling Point
1312.0±65.0 °C | Condition: Press: 760 Torr
Biological Activity
Acetylene-linker-Val-Cit-PABC-MMAE (LCB14-0602) consists the ADCs linker (Acetylene-linker-Val-Cit-PABC) and potent tubulin inhibitor (MMAE). Acetylene-linker-Val-Cit-PABC-MMAE (LCB14-0602) is a drug-linker conjugate for ADC

Acetylene-linker-Val-Cit-PABC-MMAE, a crucial chemical linker in antibody-drug conjugates (ADCs) for precise cancer therapy, boasts a multitude of applications. Here are four key applications intricately presented with high perplexity and burstiness:

Targeted Cancer Therapy: Engineered with meticulous precision, Acetylene-linker-Val-Cit-PABC-MMAE facilitates the exclusive delivery of cytotoxic agents to malignant cells by conjugating the linker to an antibody that targets tumor-specific antigens. Once bound to the cancer cell, the linker undergoes cleavage, releasing the potent tubulin inhibitor MMAE and triggering cellular demise. This targeted approach minimizes damage to healthy tissues, reducing side effects compared to conventional chemotherapy protocols.

Pharmaceutical Development: In the realm of drug development, this linker plays a pivotal role in refining the efficacy and safety profiles of novel ADCs through preclinical and clinical investigations. Researchers have the flexibility to customize the linker and payload to optimize stability, release kinetics, and therapeutic efficacy. This iterative process is essential for advancing the next generation of ADCs with heightened clinical effectiveness.

Diagnostic Tool Development: Acetylene-linker-Val-Cit-PABC-MMAE is instrumental in crafting diagnostic imaging agents that illuminate the distribution dynamics of compounds in vivo. By attaching imaging tracers to the linker, scientists can track the localization and accumulation of the conjugate within living organisms, aiding in the evaluation of tumor targeting and ADC biodistribution. This elucidation provides invaluable insights for refining therapeutic approaches.

Biomedical Research: Beyond clinical applications, this linker serves as a versatile tool for exploring drug delivery mechanisms and release kinetics in cellular environments. By unraveling the intricate behavior of the linker across diverse biological contexts, researchers can pioneer innovative strategies for designing more effective and selective therapeutic agents. Furthermore, it aids in elucidating the complexities of tumor biology and identifying novel therapeutic targets in oncology research.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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