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DBM(C6)-VC-PAB-MMAE is a thiol-reactive drug-linker conjugate used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-01408 | -- | $-- | Inquiry |
DBM(C6)-VC-PAB-MMAE, a potent antibody-drug conjugate (ADC) linker-payload system revolutionizing cancer therapeutics, introduces a groundbreaking approach for targeted treatment.
Targeted Cancer Therapy: Precision-engineered to transport cytotoxic agents directly to cancerous cells while minimizing harm to healthy tissues, DBM(C6)-VC-PAB-MMAE achieves unparalleled accuracy. By linking the payload to antibodies recognizing specific cancer cell surface markers, the payload is unleashed upon internalization, initiating precise cellular destruction with exceptional precision.
Overcoming Drug Resistance: In the realm of cancer treatment, DBM(C6)-VC-PAB-MMAE emerges as a beacon of hope in overcoming resistance encountered in conventional chemotherapy regimens. By exploiting unique biomarkers present on drug-resistant cancer cells, this ADC circumvents resistance mechanisms and efficiently delivers its cytotoxic payload. This strategic maneuver enhances therapeutic effectiveness, particularly in resistant cancer subtypes.
Improved Therapeutic Index: Pioneering cancer therapeutics, ADC technology embodied by DBM(C6)-VC-PAB-MMAE elevates the therapeutic index by offering increased efficacy at lower doses, thereby reducing systemic toxicity. By selectively releasing the cytotoxic agent in the tumor microenvironment, healthy cells are spared, resulting in fewer side effects and enhanced patient outcomes.
Combination Therapy: Embracing a multifaceted strategy in cancer care, DBM(C6)-VC-PAB-MMAE can be combined with complementary modalities, like immune checkpoint inhibitors, to amplify anticancer effects. This synergistic fusion shows potential in reducing tumor size or reshaping the tumor microenvironment to heighten responsiveness to immunotherapy.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
