CAS No.: 863971-53-3
Purity: ≥98%
HNMR
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Fmoc-Val-Cit-PAB-PNP is a cathepsin B-sensitive linker used in ADC synthesis. With a cleavable Val-Cit dipeptide and PNP activation, it enables selective payload release inside tumor cells. Suitable for advanced ADC development requiring precision and tumor-selective release.
Structure of 863971-53-3
* For research and manufacturing use only. We do not sell to patients.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| 100 mg | $159 | In stock |
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Fmoc-Val-Cit-PAB-PNP, the prized peptide linker in targeted therapeutic agent synthesis, particularly shines in the realm of antibody-drug conjugates (ADCs).
Antibody-Drug Conjugates (ADCs): Within the realm of cancer therapy, Fmoc-Val-Cit-PAB-PNP plays a pivotal role as a cleavable linker in ADC synthesis. These targeted therapies aim to combat cancer specifically. The ingenious design of the linker ensures stability in the bloodstream, yet precise cleavage in the tumor microenvironment, releasing cytotoxic drugs. This specificity not only minimizes harm to healthy cells but also maximizes the therapeutic impact on cancerous cells.
Drug Delivery Systems: Delving into the domain of drug delivery, Fmoc-Val-Cit-PAB-PNP facilitates the development of intricate systems that release therapeutic agents in response to specific triggers. This innovative linker technology empowers engineered compounds to deliver drugs with surgical precision, elevating treatment outcomes for conditions like inflammatory diseases and chronic infections.
Bioconjugation Techniques: As a fundamental component in bioconjugation methodologies, Fmoc-Val-Cit-PAB-PNP facilitates the conjugation of various molecules to peptides and proteins with unparalleled specificity. This capability proves invaluable for constructing peptide libraries, probing intricate protein interactions, and crafting diagnostic tools.
| Catalog | Product Name | CAS | Inquiry |
|---|---|---|---|
| BADC-01679 | Mal-PEG2-Val-Cit-PABA-PNP | 1345681-52-8 | |
| BADC-00929 | Fmoc-D-Val-Cit-PAB | 1350456-65-3 | |
| BADC-00849 | Acetylene-linker-Val-Cit-PABC-MMAE | 1411977-95-1 | |
| BADC-01448 | mDPR-Val-Cit-PAB-MMAE | 1491152-26-1 | |
| BADC-00958 | Amino-PEG4-Val-Cit-PAB-MMAE | 1492056-71-9 | |
| BADC-00708 | Val-cit-PAB-OH | 159857-79-1 | |
| BADC-00968 | MC-Val-Cit-PAB | 159857-80-4 | |
| BADC-00501 | Mc-Val-Cit-PABC-PNP | 159857-81-5 | |
| BADC-00364 | Fmoc-Val-Cit-PAB | 159858-22-7 | |
| BADC-01348 | Val-Cit-PAB-MMAE TFA salt | 1608127-32-7 |
Fmoc-Val-Cit-PAB-PNP
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Fmoc-Val-Cit-PAB-PNP
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