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Fmoc-D-Val-Cit-PAB

  CAS No.: 1350456-65-3   Cat No.: BADC-00929   Purity: ≥95% 4.5  

Fmoc-D-Val-Cit-PAB is a cleavable ADC linker with Val-Cit dipeptide and PAB spacer, facilitating enzymatic drug release and site-specific antibody conjugation in targeted cancer therapy.

Fmoc-D-Val-Cit-PAB

Structure of 1350456-65-3

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Category
ADC Linker
Molecular Formula
C33H39N5O6
Molecular Weight
601.69
Shipping
Room temperature
Shipping
Store at -20 °C, keep in dry and avoid sunlight.

* For research and manufacturing use only. We do not sell to patients.

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Capabilities & Facilities

Popular Publications Citing BOC Sciences Products
Synonyms
9H-Fluoren-9-ylmethyl N-[(2R)-1-[[(2S)-5-(carbamoylamino)-1-[4-(hydroxymethyl)anilino]-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate
IUPAC Name
Canonical SMILES
OCC(C=C1)=CC=C1NC([C@H](CCCNC(N)=O)NC([C@@H](C(C)C)NC(OCC2C3=CC=CC=C3C4=CC=CC=C42)=O)=O)=O
InChI
InChI=1S/C33H39N5O6/c1-20(2)29(38-33(43)44-19-27-25-10-5-3-8-23(25)24-9-4-6-11-26(24)27)31(41)37-28(12-7-17-35-32(34)42)30(40)36-22-15-13-21(18-39)14-16-22/h3-6,8-11,13-16,20,27-29,39H,7,12,17-19H2,1-2H3,(H,36,40)(H,37,41)(H,38,43)(H3,34,35,42)/t28-,29+/m0/s1
InChIKey
DALMAZHDNFCDRP-URLMMPGGSA-N
Solubility
10 mm in DMSO
Shelf Life
0-4°C for short term (days to weeks), or -20°C for long term (months).
Shipping
Room temperature
Storage
Store at -20 °C, keep in dry and avoid sunlight.

For the synthesis of antibody-drug conjugates and other bioconjugates, the versatile Fmoc-D-Val-Cit-PAB linker plays a pivotal role in advancing medical research. Here are four key applications:

Antibody-Drug Conjugates (ADCs) Development: At the forefront of targeted cancer therapies, Fmoc-D-Val-Cit-PAB stands as a cornerstone in the arena of ADCs. This specialized linker plays a crucial role in facilitating the precise release of cytotoxic drugs exclusively within tumor cells, effectively minimizing systemic toxicity.

Peptide Synthesis: Within the intricate realm of peptide synthesis, Fmoc-D-Val-Cit-PAB assumes a critical role as a fundamental building block for constructing complex peptides. Operating as a spacer unit, this linker enables the controlled liberation of desired peptides under specific conditions, ensuring purity and optimizing yield.

Prodrug Design: Harnessing the potential of Fmoc-D-Val-Cit-PAB linkers, prodrug design revolutionizes targeted drug delivery by utilizing specific biological triggers. Incorporating this advanced linker allows prodrugs to remain dormant until encountering designated enzymes or specific pH environments, triggering focused and controlled drug release.

Bioconjugation Techniques: Across diverse bioconjugation methodologies, Fmoc-D-Val-Cit-PAB empowers the attachment of functional molecules to peptides, proteins, and biomolecules, enabling the development of specialized probes for imaging, diagnostics, and therapeutics. This cutting-edge linker elevates the stability and functionality of bioconjugates, opening avenues for enhanced biomedical applications and pioneering research in the field of bioconjugation.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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