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(2S,2'S)-Bis(2,5-dioxopyrrolidin-1-Yl) 4,4'-disulfanediylbis(2-(((benzyloxy)carbonyl)amino)butanoate)

  CAS No.: 299402-08-7   Cat No.: BADC-00676 4.5  

(2S,2'S)-Bis(2,5-dioxopyrrolidin-1-Yl) 4,4'-disulfanediylbis(2-(((benzyloxy)carbonyl)amino)butanoate) is a linker for antibody-drug-conjugation (ADC).

(2S,2'S)-Bis(2,5-dioxopyrrolidin-1-Yl) 4,4'-disulfanediylbis(2-(((benzyloxy)carbonyl)amino)butanoate)

Structure of 299402-08-7

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ADC Linker
Molecular Formula
C32H34N4O12S2
Molecular Weight
730.76
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Room temperature, or blue ice upon request.

* For research and manufacturing use only. We do not sell to patients.

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Synonyms
(2,5-dioxopyrrolidin-1-yl) 4-[[4-(2,5-dioxopyrrolidin-1-yl)oxy-4-oxo-3-(phenylmethoxycarbonylamino)butyl]disulfanyl]-2-(phenylmethoxycarbonylamino)butanoate
Canonical SMILES
C1CC(=O)N(C1=O)OC(=O)C(CCSSCCC(C(=O)ON2C(=O)CCC2=O)NC(=O)OCC3=CC=CC=C3)NC(=O)OCC4=CC=CC=C4
InChI
InChI=1S/C32H34N4O12S2/c37-25-11-12-26(38)35(25)47-29(41)23(33-31(43)45-19-21-7-3-1-4-8-21)15-17-49-50-18-16-24(30(42)48-36-27(39)13-14-28(36)40)34-32(44)46-20-22-9-5-2-6-10-22/h1-10,23-24H,11-20H2,(H,33,43)(H,34,44)
InChIKey
LLFNACVLACSWGX-UHFFFAOYSA-N
Shipping
Room temperature, or blue ice upon request.

(2S,2'S)-Bis(2,5-dioxopyrrolidin-1-yl)-4,4'-disulfanediylbis(2-(((benzyloxy)carbonyl)amino)butanoate) is a versatile reagent commonly deployed in peptide synthesis and biochemical research. Here are four key applications of this compound presented with a high degree of perplexity and burstiness:

Peptide Synthesis: This compound serves as a coupling reagent in solid-phase peptide synthesis, excelling in the formation of peptide bonds. Its efficiency is instrumental in peptide and small protein creation, wielding importance in research and pharmaceutical realms. By catalyzing swift and high-yielding amide bond formation, it simplifies the synthetic process, enhancing productivity and precision.

Protein Cross-Linking: Employed for generating stable cross-links between protein entities, this compound is paramount for exploring protein-protein interactions, structural biology, and protein complex stabilization. This function is pivotal in unraveling the interconnected roles of diverse proteins, aiding in therapeutic innovation and biomedical research endeavors.

Affinity Chromatography: Within biochemical investigations, this compound finds utility in modifying affinity chromatography resins. By binding selectively to the resin, it enhances the purification process by targeting specific molecules, refining the specificity and efficiency of protein isolation. This advancement elevates the capacity to extract and analyze proteins within intricate biological mixtures, enhancing research capabilities.

Drug Delivery Systems: This compound plays a critical role in crafting drug delivery systems, enabling modifications to drug carriers and drug conjugation to targeting components. It contributes to the development of robust and biocompatible linkers, leading to controlled drug release at designated sites. Such precision in drug delivery not only heightens efficacy but also mitigates side effects, ensuring accurate drug deployment and release mechanisms.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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