MC-Alkyl-Hydrazine Modified MMAF - CAS 1404071-64-2
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MC-Alkyl-Hydrazine Modified MMAF - CAS 1404071-64-2 Catalog number: BADC-00592

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MC-Alkyl-Hydrazine Modified MMAF is a drug-linker conjugate for ADC with potent antitumor activity by using the Modified MMAF (a tubulin inhibitor), linked via the noncleavable MC-Alkyl-Hydrazine.

Category
ADCs Cytotoxin with Linkers
Product Name
MC-Alkyl-Hydrazine Modified MMAF
CAS
1404071-64-2
Catalog Number
BADC-00592
Molecular Formula
C59H92N10O12
Molecular Weight
1133.42
MC-Alkyl-Hydrazine Modified MMAF

Ordering Information

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Description
MC-Alkyl-Hydrazine Modified MMAF is a drug-linker conjugate for ADC with potent antitumor activity by using the Modified MMAF (a tubulin inhibitor), linked via the noncleavable MC-Alkyl-Hydrazine.
Synonyms
N-(4-{2-[6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]hydrazino}-4-oxobutyl)-N-methyl-L-valyl-N-[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(2S)-3-(1H-indol-3-yl)-1-(1,2-oxazinan-2-yl)-1-oxopropan-2-yl]amino}-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl}-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide; N-(4-{2-[6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]hydrazino}-4-oxobutyl)-N-methyl-L-valyl-N-[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(2S)-3-(1H-indol-3-yl)-1-{1,2-oxazinan-2-yl)-1-oxopropan-2-yl]amino}-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl}-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide
IUPAC Name
(2S)-2-[[(2S)-2-[[4-[2-[6-(2,5-dioxopyrrol-1-yl)hexanoyl]hydrazinyl]-4-oxobutyl]-methylamino]-3-methylbutanoyl]amino]-N-[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(2S)-3-(1H-indol-3-yl)-1-(oxazinan-2-yl)-1-oxopropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N,3-dimethylbutanamide
Canonical SMILES
O=C(N1CCCCO1)[C@@H](NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@@]([C@@H](C)CC)([H])N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(NNC(CCCCCN3C(C=CC3=O)=O)=O)=O)=O)=O)=O)OC)=O)CC4=CNC5=CC=CC=C45
InChI
InChI=1S/C59H92N10O12/c1-12-39(6)54(66(9)59(78)52(37(2)3)62-57(76)53(38(4)5)65(8)29-21-26-48(71)64-63-47(70)25-14-13-17-30-68-49(72)27-28-50(68)73)46(79-10)35-51(74)67-31-20-24-45(67)55(80-11)40(7)56(75)61-44(58(77)69-32-18-19-33-81-69)34-41-36-60-43-23-16-15-22-42(41)43/h15-16,22-23,27-28,36-40,44-46,52-55,60H,12-14,17-21,24-26,29-35H2,1-11H3,(H,61,75)(H,62,76)(H,63,70)(H,64,71)/t39-,40+,44-,45-,46+,52-,53-,54-,55+/m0/s1
Shipping
Room temperature
1.Antibody drug conjugates (ADC) Current status and mapping of ADC:s in clinical programs.
Samantha Congreve, Reham Faris Elias, Gabriel Tidestav, Venus Zafrianian
A literature study was performed on a new type of cancer medicine:antibody drug conjugates, or ADCs. These consist of a monoclonalantibody, chemically linked to a cytotoxic agent. What makes themunique is their selective toxicity against cancer cells. The firstapproval of such a pharmaceutical was in the year 2000, with three orfour available in different regions of the world today. In the rangeof 50 registered drugs in clinical development were found, by majorand minor corporations. These have been presented in a table in theappendix according to their properties such as type of linker,cytotoxin, development status etc. Furthermore, a detailed study hasbeen done of the chemistry of the linker conjugation as well as anattempt at studying the ADC market. Finally, the mentioned strengthsof the drug were compared to its weaknesses, mainly instability andotherwise poor pharmacokinetics. The main conclusion is that thesedrugs are expected to play a major role in oncology in the future.
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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