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DBCO-PEG4-MMAF is a drug-linker conjugate for ADC by using Monomethylauristatin F (MMAF,a potent tubulin polymerization inhibitor), linked via DBCO-PEG4.
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-00751 | -- | $-- | Inquiry |
DBCO-PEG4-MMAF, a bioconjugate linker, is essential for synthesizing antibody-drug conjugates (ADCs) with profound applications in targeted cancer therapy. Discover the versatility of DBCO-PEG4-MMAF through these four key applications:
Cancer Therapy: Unveil the transformative potential of DBCO-PEG4-MMAF in steering the evolution of antibody-drug conjugates (ADCs) tailored for precision cancer treatment. By coupling the cytotoxic agent MMAF with a tumor-specific antibody, ADCs can unleash targeted destruction on cancer cells while safeguarding healthy tissues from harm. This meticulous strategy not only mitigates side effects but also elevates the therapeutic efficacy of anticancer agents to new heights.
Drug Development: Dive into the realm of pharmaceutical innovation, where DBCO-PEG4-MMAF emerges as a pivotal building block for engineering novel drug candidates. Its integration into ADCs empowers researchers to craft and evaluate cutting-edge therapies boasting superior potency and selectivity. The precise linkage chemistry facilitated by DBCO-PEG4-MMAF ensures robust drug attachment and controlled release, propelling the creation of next-generation therapeutics forward.
Molecular Biology Research: Explore the intricate dance of drug mechanisms and antibody internalization in molecular biology, facilitated by the versatile capabilities of DBCO-PEG4-MMAF. By monitoring the delivery and uptake of ADCs within cellular systems, scientists unravel the molecular intricacies governing the functionality of these conjugates. This deep understanding forms the bedrock for refining ADC design and prognosticating clinical outcomes with precision.
Preclinical Studies: Embark on a journey through preclinical evaluation realms, where DBCO-PEG4-MMAF plays an indispensable role in scrutinizing the safety and efficacy of emerging ADC candidates. Animal models treated with DBCO-PEG4-MMAF-conjugated ADCs yield crucial insights into pharmacokinetics, biodistribution, and antitumor activity. This rigorous preclinical assessment steers ADCs along the developmental trajectory, ushering them from lab bench to the clinical trial arena with confidence and purpose.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
