Mc-MMAF - CAS 863971-19-1

Mc-MMAF - CAS 863971-19-1 Catalog number: BADC-00014

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Mc-MMAF is a protective group-conjugated MMAF, MMAF is an antitubulin agent that inhibit cell division by blocking the polymerization of tubulin and it has lower cytotoxic activity than MMAE.

General Information

Category
ADCs Cytotoxin with Linkers
Product Name
Mc-MMAF
CAS
863971-19-1
Catalog Number
BADC-00014
Molecular Formula
C49H76N6O11
Molecular Weight
925.18

Chemical Structure

  • Mc-MMAF

Ordering Information

Catalog Number Size Price Stock Quantity
BADC-00014 1 mg $499 In stock
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Purity
≥98%
Appearance
Soild powder
Synonyms
SGD-1269; SGD 1269; SGD1269; mc-MMAF; mcMMAF; L4-MMAF; Maleimidocaproyl-MMAF; Maleimidocaproyl monomethylauristatin F; Mafodotin.((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-2-((S)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-methylhexanamido)-3-methylbutanamido)-N,3-dimethylbutanamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoyl)-L-phenylalanine
Solubility
10 mM in DMSO
Storage
-20°C Freezer
Application
SGD 1269 is a potent tubulin inhibitor and is a toxin payload in antibody drug conjugate. It is a useful agent for make antibody drug conjugate (ADC) for targeted drug delivery.
Quality Standard
In-house standard
Shelf Life
2 month in rt, long time
Quantity
Milligrams-Grams
Boiling Point
1052.0±65.0 °C | Condition: Press: 760 Torr
Density
1.167±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
Canonical SMILES
O=C(O)[C@H](CC1=CC=CC=C1)NC([C@H](C)[C@H]([C@H]2N(C(C[C@@H](OC)[C@@H](N(C)C([C@@H](NC([C@@H](N(C)C(CCCCCN3C(C=CC3=O)=O)=O)C(C)C)=O)C(C)C)=O)[C@@H](C)CC)=O)CCC2)OC)=O
InChI Key
ORFNVPGICPYLJV-YTVPMEHESA-N
InChI
InChI=1S/C49H76N6O11/c1-12-32(6)44(37(65-10)29-41(59)54-27-19-22-36(54)45(66-11)33(7)46(60)50-35(49(63)64)28-34-20-15-13-16-21-34)53(9)48(62)42(30(2)3)51-47(61)43(31(4)5)52(8)38(56)23-17-14-18-26-55-39(57)24-25-40(55)58/h13,15-16,20-21,24-25,30-33,35-37,42-45H,12,14,17-19,22-23,26-29H2,1-11H3,(H,50,60)(H,51,61)(H,63,64)/t32-,33+,35-,36-,37+,42-,43-,44-,45+/m0/s1

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