Name: AZ1508
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Synonyms

AZ1508; AZ 1508; AZ-1508; MC-Lys-MMETA; (2S,4R)-4-[[2-[(1R,3R)-1-acetyloxy-3-[[(2S,3S)-2-[[(2R,4R)-1,4-dimethylpiperidine-2-carbonyl]amino]-3-methylpentanoyl]-ethylamino]-4-methylpentyl]-1,3-thiazole-4-carbonyl]amino]-5-[4-[[(2S)-6-amino-2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]hexanoyl]amino]phenyl]-2-methylpentanoic acid

IUPAC Name

(2S,4R)-4-[[2-[(1R,3R)-1-acetyloxy-3-[[(2S,3S)-2-[[(2R,4R)-1,4-dimethylpiperidine-2-carbonyl]amino]-3-methylpentanoyl]-ethylamino]-4-methylpentyl]-1,3-thiazole-4-carbonyl]amino]-5-[4-[[(2S)-6-amino-2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]hexanoyl]amino]phenyl]-2-methylpentanoic acid

Canonical SMILES

CCC(C)C(C(=O)N(CC)C(CC(C1=NC(=CS1)C(=O)NC(CC2=CC=C(C=C2)NC(=O)C(CCCCN)NC(=O)CCCCCN3C(=O)C=CC3=O)CC(C)C(=O)O)OC(=O)C)C(C)C)NC(=O)C4CC(CCN4C)C

InChI

InChI=1S/C56H85N9O11S/c1-10-36(6)50(62-53(72)45-29-35(5)25-28-63(45)9)55(73)64(11-2)44(34(3)4)32-46(76-38(8)66)54-61-43(33-77-54)52(71)59-41(30-37(7)56(74)75)31-39-19-21-40(22-20-39)58-51(70)42(17-14-15-26-57)60-47(67)18-13-12-16-27-65-48(68)23-24-49(65)69/h19-24,33-37,41-42,44-46,50H,10-18,25-32,57H2,1-9H3,(H,58,70)(H,59,71)(H,60,67)(H,62,72)(H,74,75)/t35-,36+,37+,41-,42+,44-,45-,46-,50+/m1/s1

InChIKey

DONIIAXVJUFSOY-FJTITLMZSA-N

Shipping

Room temperature, or blue ice upon request.

In Vivo

Anti-EphA2 DA-ADCs containing AZ1508 or SG3249 maleimide drug-linkers were potent inhibitors of tumor growth in PC3 tumor models in vivo.

AZ1508, a compound of remarkable versatility, finds widespread applications in both scientific research and industry. Here, we explore four key applications of AZ1508 with a high degree of perplexity and burstiness:

Cancer Research: Delving into oncology research, AZ1508 serves as a cornerstone in comprehending its impact on cancer cell proliferation and apoptosis. By unraveling its intricate interactions with specific cellular pathways, researchers strive to unveil potential therapeutic targets for combating cancer. Studies involving AZ1508 may pave the way for the development of novel anti-cancer medications that promise enhanced patient outcomes.

Drug Development: Positioned as a beacon in the realm of drug discovery, AZ1508 undergoes rigorous scrutiny for its pharmacological attributes and therapeutic potentials. Its multifaceted efficacy in modulating diverse biological targets renders it an attractive candidate for addressing ailments beyond cancer, spanning from autoimmune disorders to neurological conditions.

Neuroscience: Within the realm of neuroscience, AZ1508 emerges as a pivotal element in unraveling neuronal function and signaling complexities. By probing its effects on neurotransmitter systems, scientists glean insights into the molecular underpinnings of neurological maladies such as Alzheimer's and Parkinson's diseases.

Immunology: At the forefront of immunology, AZ1508 plays a pivotal role in elucidating immune cell modulation and inflammatory responses. Guiding researchers in understanding the nuances of immune system regulation, AZ1508 becomes instrumental in devising therapies for autoimmune conditions and chronic inflammatory disorders. Its ability to influence immune pathways underscores its significance in crafting immunomodulatory treatments aimed at restoring immune balance and alleviating inflammatory burdens.