AZ1508 - CAS 1817736-04-1

AZ1508 - CAS 1817736-04-1 Catalog number: BADC-00619

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AZ1508 is a drug-linker conjugates for ADC for the treatment of breast and stomach cancer, and the drug is a tubulin inhibitor.

Category
ADCs Cytotoxin with Linkers
Product Name
AZ1508
CAS
1817736-04-1
Catalog Number
BADC-00619
Molecular Formula
C56H85N9O11S
Molecular Weight
1092.39
AZ1508

Ordering Information

Catalog Number Size Price Quantity
BADC-00619 -- $-- Inquiry
Description
AZ1508 is a drug-linker conjugates for ADC for the treatment of breast and stomach cancer, and the drug is a tubulin inhibitor.
Synonyms
AZ1508; AZ 1508; AZ-1508; MC-Lys-MMETA; (2S,4R)-4-[[2-[(1R,3R)-1-acetyloxy-3-[[(2S,3S)-2-[[(2R,4R)-1,4-dimethylpiperidine-2-carbonyl]amino]-3-methylpentanoyl]-ethylamino]-4-methylpentyl]-1,3-thiazole-4-carbonyl]amino]-5-[4-[[(2S)-6-amino-2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]hexanoyl]amino]phenyl]-2-methylpentanoic acid
IUPAC Name
(2S,4R)-4-[[2-[(1R,3R)-1-acetyloxy-3-[[(2S,3S)-2-[[(2R,4R)-1,4-dimethylpiperidine-2-carbonyl]amino]-3-methylpentanoyl]-ethylamino]-4-methylpentyl]-1,3-thiazole-4-carbonyl]amino]-5-[4-[[(2S)-6-amino-2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]hexanoyl]amino]phenyl]-2-methylpentanoic acid
Canonical SMILES
CCC(C)C(C(=O)N(CC)C(CC(C1=NC(=CS1)C(=O)NC(CC2=CC=C(C=C2)NC(=O)C(CCCCN)NC(=O)CCCCCN3C(=O)C=CC3=O)CC(C)C(=O)O)OC(=O)C)C(C)C)NC(=O)C4CC(CCN4C)C
InChI
InChI=1S/C56H85N9O11S/c1-10-36(6)50(62-53(72)45-29-35(5)25-28-63(45)9)55(73)64(11-2)44(34(3)4)32-46(76-38(8)66)54-61-43(33-77-54)52(71)59-41(30-37(7)56(74)75)31-39-19-21-40(22-20-39)58-51(70)42(17-14-15-26-57)60-47(67)18-13-12-16-27-65-48(68)23-24-49(65)69/h19-24,33-37,41-42,44-46,50H,10-18,25-32,57H2,1-9H3,(H,58,70)(H,59,71)(H,60,67)(H,62,72)(H,74,75)/t35-,36+,37+,41-,42+,44-,45-,46-,50+/m1/s1
InChIKey
DONIIAXVJUFSOY-FJTITLMZSA-N
Shipping
Room temperature, or blue ice upon request.
In Vivo
Anti-EphA2 DA-ADCs containing AZ1508 or SG3249 maleimide drug-linkers were potent inhibitors of tumor growth in PC3 tumor models in vivo.

AZ1508, a compound of remarkable versatility, finds widespread applications in both scientific research and industry. Here, we explore four key applications of AZ1508 with a high degree of perplexity and burstiness:

Cancer Research: Delving into oncology research, AZ1508 serves as a cornerstone in comprehending its impact on cancer cell proliferation and apoptosis. By unraveling its intricate interactions with specific cellular pathways, researchers strive to unveil potential therapeutic targets for combating cancer. Studies involving AZ1508 may pave the way for the development of novel anti-cancer medications that promise enhanced patient outcomes.

Drug Development: Positioned as a beacon in the realm of drug discovery, AZ1508 undergoes rigorous scrutiny for its pharmacological attributes and therapeutic potentials. Its multifaceted efficacy in modulating diverse biological targets renders it an attractive candidate for addressing ailments beyond cancer, spanning from autoimmune disorders to neurological conditions.

Neuroscience: Within the realm of neuroscience, AZ1508 emerges as a pivotal element in unraveling neuronal function and signaling complexities. By probing its effects on neurotransmitter systems, scientists glean insights into the molecular underpinnings of neurological maladies such as Alzheimer's and Parkinson's diseases.

Immunology: At the forefront of immunology, AZ1508 plays a pivotal role in elucidating immune cell modulation and inflammatory responses. Guiding researchers in understanding the nuances of immune system regulation, AZ1508 becomes instrumental in devising therapies for autoimmune conditions and chronic inflammatory disorders. Its ability to influence immune pathways underscores its significance in crafting immunomodulatory treatments aimed at restoring immune balance and alleviating inflammatory burdens.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Historical Records: Mal-Phe-C4-VC-PAB-MMAE | AZ1508
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