Mal-amide-PEG3-CH2 NHS ester - CAS 2101206-45-3

Mal-amide-PEG3-CH2 NHS ester - CAS 2101206-45-3 Catalog number: BADC-00647

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Mal-amide-PEG3-CH2 NHS ester is a PEGn linker for antibody-drug-conjugation (ADC).

Category
ADCs Linker
Product Name
Mal-amide-PEG3-CH2 NHS ester
CAS
2101206-45-3
Catalog Number
BADC-00647
Molecular Formula
C19H25N3O10
Molecular Weight
455.42

Ordering Information

Catalog Number Size Price Quantity
BADC-00647 -- $-- Inquiry
Description
Mal-amide-PEG3-CH2 NHS ester is a PEGn linker for antibody-drug-conjugation (ADC).
Synonyms
2, 5-Dioxopyrrolidin-1-yl 15-(2, 5-dioxo-2H-pyrrol-1(5H)-yl)-13-oxo-3, 6, 9-trioxa-12-azapentadecan-1-oate; (2,5-dioxopyrrolidin-1-yl) 2-[2-[2-[2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]ethoxy]ethoxy]ethoxy]acetate
IUPAC Name
(2,5-dioxopyrrolidin-1-yl) 2-[2-[2-[2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]ethoxy]ethoxy]ethoxy]acetate
Canonical SMILES
C1CC(=O)N(C1=O)OC(=O)COCCOCCOCCNC(=O)CCN2C(=O)C=CC2=O
InChI
InChI=1S/C19H25N3O10/c23-14(5-7-21-15(24)1-2-16(21)25)20-6-8-29-9-10-30-11-12-31-13-19(28)32-22-17(26)3-4-18(22)27/h1-2H,3-13H2,(H,20,23)
InChIKey
HMTNEILNSWIWRP-UHFFFAOYSA-N
Shipping
Room temperature

Mal-amide-PEG3-CH2 NHS ester is a highly reactive compound widely used in the field of bioconjugation for the development of targeted drug delivery systems. The compound consists of a malonic acid group, an amide linker, a polyethylene glycol (PEG) chain, and an NHS ester (N-hydroxysuccinimide ester) functional group. The NHS ester is highly reactive with primary amines, making it an ideal tool for conjugating a variety of biomolecules, such as proteins, peptides, or antibodies, to the PEG linker. This reaction allows for the creation of stable, well-defined conjugates that can be used in targeted therapies, such as antibody-drug conjugates (ADCs), where drugs are selectively delivered to specific tissues, reducing off-target toxicity.

Another important application of Mal-amide-PEG3-CH2 NHS ester is in the development of PEGylated therapeutics. The PEG chain enhances the solubility, stability, and circulation time of the conjugated drug, providing a longer half-life in the bloodstream and reducing the likelihood of rapid clearance by the immune system. By attaching this compound to drugs or biologics, researchers can improve their pharmacokinetics, allowing for lower dosing frequencies and improved patient compliance. This application is particularly useful in the development of long-acting biologics, such as monoclonal antibodies, enzymes, and peptide-based drugs, where sustained therapeutic levels are required over time.

Mal-amide-PEG3-CH2 NHS ester also plays a critical role in the creation of targeted imaging agents. By conjugating this compound to imaging molecules like fluorescent dyes, radiolabels, or nanoparticles, it is possible to create highly specific probes for in vivo imaging. The PEG linker provides enhanced solubility and stability, while the NHS ester facilitates the conjugation of the imaging agent to biomolecules that can target specific tissues or receptors. This application is particularly valuable in molecular imaging, where precise visualization of tumors, infections, or other pathological conditions is needed for early diagnosis and monitoring of therapeutic responses. The use of Mal-amide-PEG3-CH2 NHS ester in these systems improves the specificity and reliability of the imaging process.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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