Name: Mal-amide-PEG3-CH2 NHS ester
Brand: BOC Sciences
Rating: 5 (1 reviews)

Synonyms

2, 5-Dioxopyrrolidin-1-yl 15-(2, 5-dioxo-2H-pyrrol-1(5H)-yl)-13-oxo-3, 6, 9-trioxa-12-azapentadecan-1-oate; (2,5-dioxopyrrolidin-1-yl) 2-[2-[2-[2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]ethoxy]ethoxy]ethoxy]acetate

IUPAC Name

(2,5-dioxopyrrolidin-1-yl) 2-[2-[2-[2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]ethoxy]ethoxy]ethoxy]acetate

Canonical SMILES

C1CC(=O)N(C1=O)OC(=O)COCCOCCOCCNC(=O)CCN2C(=O)C=CC2=O

InChI

InChI=1S/C19H25N3O10/c23-14(5-7-21-15(24)1-2-16(21)25)20-6-8-29-9-10-30-11-12-31-13-19(28)32-22-17(26)3-4-18(22)27/h1-2H,3-13H2,(H,20,23)

InChIKey

HMTNEILNSWIWRP-UHFFFAOYSA-N

Shipping

Room temperature

Mal-amide-PEG3-CH2 NHS ester is a highly reactive compound widely used in the field of bioconjugation for the development of targeted drug delivery systems. The compound consists of a malonic acid group, an amide linker, a polyethylene glycol (PEG) chain, and an NHS ester (N-hydroxysuccinimide ester) functional group. The NHS ester is highly reactive with primary amines, making it an ideal tool for conjugating a variety of biomolecules, such as proteins, peptides, or antibodies, to the PEG linker. This reaction allows for the creation of stable, well-defined conjugates that can be used in targeted therapies, such as antibody-drug conjugates (ADCs), where drugs are selectively delivered to specific tissues, reducing off-target toxicity.

Another important application of Mal-amide-PEG3-CH2 NHS ester is in the development of PEGylated therapeutics. The PEG chain enhances the solubility, stability, and circulation time of the conjugated drug, providing a longer half-life in the bloodstream and reducing the likelihood of rapid clearance by the immune system. By attaching this compound to drugs or biologics, researchers can improve their pharmacokinetics, allowing for lower dosing frequencies and improved patient compliance. This application is particularly useful in the development of long-acting biologics, such as monoclonal antibodies, enzymes, and peptide-based drugs, where sustained therapeutic levels are required over time.

Mal-amide-PEG3-CH2 NHS ester also plays a critical role in the creation of targeted imaging agents. By conjugating this compound to imaging molecules like fluorescent dyes, radiolabels, or nanoparticles, it is possible to create highly specific probes for in vivo imaging. The PEG linker provides enhanced solubility and stability, while the NHS ester facilitates the conjugation of the imaging agent to biomolecules that can target specific tissues or receptors. This application is particularly valuable in molecular imaging, where precise visualization of tumors, infections, or other pathological conditions is needed for early diagnosis and monitoring of therapeutic responses. The use of Mal-amide-PEG3-CH2 NHS ester in these systems improves the specificity and reliability of the imaging process.