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Mal-amide-PEG8-Val-Ala-PAB-PNP

  CAS No.: 2210247-59-7   Cat No.: BADC-01428   Purity: ≥95% 4.5  

Mal-amide-PEG8-Val-Ala-PAB-PNP is a maleimide-functionalized cleavable ADC linker featuring a Val-Ala dipeptide and PAB spacer for enzyme-triggered payload release in antibody-drug conjugates. Keywords: ADC linker, cleavable linker, maleimide linker, peptide linker, controlled release.

Mal-amide-PEG8-Val-Ala-PAB-PNP

Structure of 2210247-59-7

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Category
ADC Linker
Molecular Formula
C48H68N6O19
Molecular Weight
1033.10
Shipping
Store at -20°C, sealed storage, away from moisture

* For research and manufacturing use only. We do not sell to patients.

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Synonyms
MA-PEG8-VA-PAB-PNP; N-[31-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-29-oxo-4,7,10,13,16,19,22,25-octaoxa-28-azahentriacontan-1-oyl]-L-valyl-N-[4-({[(4-nitrophenoxy)carbonyl]oxy}methyl)phenyl]-L-alaninamide; L-Alaninamide, N-[31-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1,29-dioxo-4,7,10,13,16,19,22,25-octaoxa-28-azahentriacont-1-yl]-L-valyl-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-; 4-((2S,5S)-37-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5-isopropyl-2-methyl-4,7,35-trioxo-10,13,16,19,22,25,28,31-octaoxa-3,6,34-triazaheptatriacontanamido)benzyl (4-nitrophenyl) carbonate; VA-5
IUPAC Name
[4-[[(2S)-2-[[(2S)-2-[3-[2-[2-[2-[2-[2-[2-[2-[2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoylamino]-3-methylbutanoyl]amino]propanoyl]amino]phenyl]methyl (4-nitrophenyl) carbonate
Canonical SMILES
CC(C)C(C(=O)NC(C)C(=O)NC1=CC=C(C=C1)COC(=O)OC2=CC=C(C=C2)[N+](=O)[O-])NC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCN3C(=O)C=CC3=O
InChI
InChI=1S/C48H68N6O19/c1-35(2)45(47(60)50-36(3)46(59)51-38-6-4-37(5-7-38)34-72-48(61)73-40-10-8-39(9-11-40)54(62)63)52-42(56)15-18-64-20-22-66-24-26-68-28-30-70-32-33-71-31-29-69-27-25-67-23-21-65-19-16-49-41(55)14-17-53-43(57)12-13-44(53)58/h4-13,35-36,45H,14-34H2,1-3H3,(H,49,55)(H,50,60)(H,51,59)(H,52,56)/t36-,45-/m0/s1
InChIKey
XKNFUEHAHZGFPB-PXQFAMQDSA-N
Density
1.270±0.06 g/cm3
Appearance
Viscous Liquid
Storage
Store at -20°C, sealed storage, away from moisture
Boiling Point
1146.3±65.0°C at 760 mmHg

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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