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CAS No.:
Cat No.: BADC-01267
Purity: ≥95%
4.5 
Mal-amido-PEG2-Val-Cit-PAB-OH is a maleimide cleavable ADC linker with PEG2 spacer and Val-Cit-PABC peptide for enzymatic drug release. Enhances stability and conjugation efficiency in ADCs.
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Mal-amido-PEG2-Val-Cit-PAB-OH is a chemical linker commonly used in the development of antibody-drug conjugates (ADCs) and other drug delivery systems. Here are some key applications of Mal-amido-PEG2-Val-Cit-PAB-OH:
Antibody-Drug Conjugates (ADCs): Mal-amido-PEG2-Val-Cit-PAB-OH is integral in the design of ADCs, where it acts as a stable yet cleavable linker between the antibody and therapeutic agent. This linker ensures the stable delivery of the drug to the target site and releases the drug upon internalization into target cells. The valine-citrulline dipeptide sequence is responsible for the linker’s cleavage inside lysosomes, ensuring controlled drug release and minimizing off-target effects.
Targeted Cancer Therapy: By facilitating the conjugation of cytotoxic drugs to targeting antibodies, Mal-amido-PEG2-Val-Cit-PAB-OH plays a crucial role in the development of targeted cancer therapies. Its design allows for precise delivery of potent chemotherapeutic agents to cancer cells, sparing healthy cells and reducing systemic toxicity. This approach enhances the therapeutic index of anticancer drugs, improving efficacy and patient outcomes.
Bioconjugation Research: Researchers use Mal-amido-PEG2-Val-Cit-PAB-OH in bioconjugation applications to study complex biological processes. Its bifunctional nature allows for precise attachment of biomolecules to proteins, facilitating the creation of bioconjugates for mechanistic studies and biomarker identification. This approach is valuable for both in vitro and in vivo studies, advancing our understanding of molecular interactions.
Drug Delivery Systems: In the broader field of drug delivery, Mal-amido-PEG2-Val-Cit-PAB-OH is employed to create versatile delivery platforms. Its PEG (polyethylene glycol) moiety provides solubility and biocompatibility, while the cleavable linker ensures drug activation at the target site. This is essential for developing advanced delivery technologies that improve drug pharmacokinetics, reduce side effects, and enhance therapeutic outcomes.
| Catalog | Product Name | CAS | Inquiry |
|---|---|---|---|
| BADC-01679 | Mal-PEG2-Val-Cit-PABA-PNP | 1345681-52-8 | |
| BADC-00929 | Fmoc-D-Val-Cit-PAB | 1350456-65-3 | |
| BADC-00849 | Acetylene-linker-Val-Cit-PABC-MMAE | 1411977-95-1 | |
| BADC-01448 | mDPR-Val-Cit-PAB-MMAE | 1491152-26-1 | |
| BADC-00958 | Amino-PEG4-Val-Cit-PAB-MMAE | 1492056-71-9 | |
| BADC-00708 | Val-cit-PAB-OH | 159857-79-1 | |
| BADC-00968 | MC-Val-Cit-PAB | 159857-80-4 | |
| BADC-00501 | Mc-Val-Cit-PABC-PNP | 159857-81-5 | |
| BADC-00364 | Fmoc-Val-Cit-PAB | 159858-22-7 | |
| BADC-01348 | Val-Cit-PAB-MMAE TFA salt | 1608127-32-7 |
Mal-amido-PEG2-Val-Cit-PAB-OH
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Mal-amido-PEG2-Val-Cit-PAB-OH
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