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CAS No.: 756525-98-1
Cat No.: BADC-01578
Purity: >97%
4.5 
Mal-amido-PEG2-acid is a maleimide-functionalized ADC linker enabling site-specific antibody conjugation with enhanced stability and optimized payload attachment for improved targeted therapy outcomes.
Structure of 756525-98-1
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Popular Publications Citing BOC Sciences Products
Mal-amido-PEG2-acid, a pivotal bifunctional polyethylene glycol (PEG) derivative, is instrumental in bioconjugation and drug delivery systems.
Bioconjugation: Mal-amido-PEG2-acid plays a vital role in covalently attaching proteins, peptides, or biomolecules to surfaces or macromolecules. By seamlessly integrating PEG into the structure, it elevates the solubility and stability of these bioconjugates, offering a valuable technique for developing targeted therapeutics and enhancing pharmacokinetics for biologics.
Drug Delivery: Mal-amido-PEG2-acid serves as a crucial linker, enabling the conjugation of drugs with PEG to create PEGylated drugs with extended circulation times. This transformative modification reduces immunogenicity, enhances drug solubility, and ultimately amplifies therapeutic efficacy, particularly in crafting sustained-release formulations for protein and peptide-based medications.
Diagnostics: Mal-amido-PEG2-acid elevates biosensor performance by facilitating the attachment of biomolecules to sensor surfaces. This enhancement in sensitivity and specificity is paramount for developing reliable assays in clinical diagnostics, such as immunoassays and nucleic acid detection, underscoring its pivotal role in advancing diagnostic technologies.
Nanomedicine: Unveil the critical role of Mal-amido-PEG2-acid in the realm of nanomedicine, where it functions in the functionalization of nanoparticles for targeted drug delivery and imaging applications. The incorporation of the PEG linker combats nanoparticle aggregation, enhances biocompatibility, and is essential for achieving precise targeting and minimizing off-target effects in therapeutic and diagnostic applications.
| Catalog | Product Name | CAS | Inquiry |
|---|---|---|---|
| BADC-00584 | Mal-amido-PEG8-acid | 1334177-86-4 | |
| BADC-01740 | Mal-amido-PEG9-Val-Ala-PAB-SG3200 | 1817788-75-2 | |
| BADC-01052 | Mal-amido-(CH2COOH)2 | 207613-14-7 | |
| BADC-01066 | Mal-amido-PEG2-Val-Cit-PAB-PNP | 2112738-13-1 | |
| BADC-01097 | Mal-amido-PEG8-val-gly-PAB-OH | 2353409-52-4 | |
| BADC-00447 | Mal-amido-PEG2-NHS | 955094-26-5 | |
| BADC-01267 | Mal-amido-PEG2-Val-Cit-PAB-OH |
What is the role of Mal-amido-PEG2-acid in ADC conjugation?
Mal-amido-PEG2-acid serves as a maleimide-functionalized linker that enables selective thiol conjugation to antibodies or payloads. Its PEG2 spacer enhances solubility and reduces steric hindrance, improving conjugation efficiency and ADC stability.
25/10/2017
Dear team, how does Mal-amido-PEG2-acid contribute to controlled drug release?
The maleimide group in Mal-amido-PEG2-acid forms stable thioether bonds with cysteine residues on antibodies, allowing precise attachment of payloads. Its PEG2 spacer maintains flexibility, supporting controlled intracellular drug release.
28/11/2020
Dear team, can Mal-amido-PEG2-acid be used with different antibodies?
Yes, Mal-amido-PEG2-acid is compatible with antibodies containing accessible thiol groups. The maleimide chemistry is widely applicable, and the PEG2 spacer reduces aggregation, supporting diverse ADC designs.
22/7/2018
Good morning! Which techniques can verify Mal-amido-PEG2-acid conjugation?
Conjugation can be confirmed using HPLC for purity, mass spectrometry for molecular weight verification, and SDS-PAGE or LC-MS to confirm antibody modification and payload attachment.
21/12/2019
Good morning! What are the recommended storage conditions and stability considerations for Mal-amido-PEG2-acid?
Mal-amido-PEG2-acid should be stored at low temperatures, preferably under inert atmosphere and protected from light and moisture. Stability assessments indicate that minimizing exposure to heat and aqueous environments preserves its functional integrity, ensuring reliable performance in conjugation reactions.
17/7/2018
— Dr. Michael Scott, Senior Chemist (USA)
Mal-amido-PEG2-acid enabled efficient maleimide-thiol conjugations with high yield.
22/7/2018
— Ms. Emily Fischer, Biochemist (Germany)
High purity and solubility ensured smooth multi-step synthesis.
17/7/2018
— Dr. Thomas White, ADC Scientist (UK)
The linker performed reliably in our ADC conjugation protocols.
21/12/2019
— Dr. Isabelle Laurent, Medicinal Chemist (France)
Minimal side reactions ensured excellent product quality.
25/10/2017
— Dr. Leo Fischer, Chemist (Germany)
Using this product, we explored innovative drug-release mechanisms.
— Prof. Isabelle Martin, Medicinal Chemist (France)
Mal-amido-PEG2-acid was integral to our ADC linker development. The product’s stability and solubility exceeded our expectations.
28/11/2020
Mal-amido-PEG2-acid
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Mal-amido-PEG2-acid
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