Mal-amido-PEG8-acid is a PEG derivative containing a maleimide group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.
Structure of 1334177-86-4
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Capabilities & Facilities
Mal-amido-PEG8-acid is a versatile compound used extensively in biochemical and pharmaceutical research due to its unique properties. Here are some key applications of Mal-amido-PEG8-acid:
Bioconjugation: Mal-amido-PEG8-acid is often used in bioconjugation to link biomolecules, such as proteins and peptides, with various labels or carriers. Its maleimide group specifically reacts with thiol groups to form stable thioether bonds, making it ideal for creating targeted drug delivery systems. This application is crucial for developing novel therapeutics where precise molecular alignment is essential.
Drug Delivery Systems: In pharmaceutical sciences, Mal-amido-PEG8-acid plays a role in the formation of drug delivery systems. By attaching drugs to PEGylated compounds, it enhances solubility, stability, and bioavailability, leading to improved pharmacokinetic profiles. This approach is especially beneficial for delivering cancer therapeutics, offering targeted action with reduced side effects.
Surface Modification: Mal-amido-PEG8-acid is used to modify surfaces of nanoparticles or medical devices to enhance biocompatibility. Its PEGylation properties help reduce protein adsorption and cellular uptake, minimizing immune recognition and clearance. This application is crucial in developing implants and biosensors with prolonged in vivo stability.
Diagnostics: Mal-amido-PEG8-acid is employed in the design of diagnostic tools, where it facilitates attachment of dyes or markers to molecules. By enabling precise conjugation to antibodies or nucleic acids, it improves the sensitivity and specificity of assays.
Catalog | Product Name | CAS | Inquiry |
---|---|---|---|
BADC-01740 | Mal-amido-PEG9-Val-Ala-PAB-SG3200 | 1817788-75-2 | |
BADC-01052 | Mal-amido-(CH2COOH)2 | 207613-14-7 | |
BADC-01066 | Mal-amido-PEG2-Val-Cit-PAB-PNP | 2112738-13-1 | |
BADC-01097 | Mal-amido-PEG8-val-gly-PAB-OH | 2353409-52-4 | |
BADC-01578 | Mal-amido-PEG2-acid | 756525-98-1 | |
BADC-00447 | Mal-amido-PEG2-NHS | 955094-26-5 | |
BADC-01267 | Mal-amido-PEG2-Val-Cit-PAB-OH |
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