Mal-VC-PAB-ABAEP-Azonafide - CAS 2259318-48-2
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Mal-VC-PAB-ABAEP-Azonafide - CAS 2259318-48-2 Catalog number: BADC-00669

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Mal-VC-PAB-ABAEP-Azonafide is a drug-linker conjugate for ADC with with potent antitumor activity by using Azonafide (a cytotoxin), linked via the ADC linker Mal-VC-PAB.

Category
ADCs Cytotoxin with Linkers
Product Name
Mal-VC-PAB-ABAEP-Azonafide
CAS
2259318-48-2
Catalog Number
BADC-00669
Molecular Formula
C61H71N11O12
Molecular Weight
1150.28
Mal-VC-PAB-ABAEP-Azonafide

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Description
Mal-VC-PAB-ABAEP-Azonafide is a drug-linker conjugate for ADC with with potent antitumor activity by using Azonafide (a cytotoxin), linked via the ADC linker Mal-VC-PAB.
IUPAC Name
[4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl N-[4-[2-[4-[2-(10-methoxy-14,16-dioxo-15-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1(17),2,4,6,8,10,12-heptaen-15-yl)ethyl]piperazin-1-yl]ethylcarbamoyl]phenyl]carbamate
Canonical SMILES
O=C(N1CCN2CCN(CCNC(C3=CC=C(NC(OCC4=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN5C(C=CC5=O)=O)=O)=O)=O)C=C4)=O)C=C3)=O)CC2)C6=C7C(C(OC)=CC=C7C1=O)=CC8=CC=CC=C68
InChI
InChI=1S/C61H71N11O12/c1-38(2)54(68-49(73)13-5-4-8-28-71-50(74)24-25-51(71)75)57(78)67-47(12-9-26-64-60(62)81)56(77)65-42-18-14-39(15-19-42)37-84-61(82)66-43-20-16-40(17-21-43)55(76)63-27-29-69-30-32-70(33-31-69)34-35-72-58(79)45-22-23-48(83-3)46-36-41-10-6-7-11-44(41)53(52(45)46)59(72)80/h6-7,10-11,14-25,36,38,47,54H,4-5,8-9,12-13,26-35,37H2,1-3H3,(H,63,76)(H,65,77)(H,66,82)(H,67,78)(H,68,73)(H3,62,64,81)/t47-,54-/m0/s1
Shipping
Room temperature
1.ROR1 ANTIBODY IMMUNOCONJUGATES
LANNUTTI, Brian, et al.
Cancer is the second leading cause of human death next to coronary artery disease.Receptor tyrosine kinases (RTKs) play a key role in oncogenic transformation, growth andmetastases. RTKs regulate cell differentiation, proliferation, migration, angiogenesis, andsurvival. The receptor tyrosine kinase-like orphan receptor 1 (ROR1) is an evolutionarilyconserved type I membrane protein that belongs to the ROR subfamily and has extracellulardomains that contain immunoglobulin (Ig)-like, Frizzled, and Kringle domains. ROR 1-deficientmice display a variety of phenotypic defects within the skeletal and urogenital systems, as wellas postnatal growth retardation. ROR1 is expressed during embryogenesis and by a variety ofdifferent cancers, but not by normal post-partum tissues, and can be considered an oncoembryonic surface antigen. Functional data suggest that ROR1 may function in non-canonicalWNT-signaling to promote the survival of malignant cells.
The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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