Mal-VC-PAB-ABAEP-Azonafide - CAS 2259318-48-2

Mal-VC-PAB-ABAEP-Azonafide - CAS 2259318-48-2 Catalog number: BADC-00669

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Mal-VC-PAB-ABAEP-Azonafide is a drug-linker conjugate for ADC with with potent antitumor activity by using Azonafide (a cytotoxin), linked via the ADC linker Mal-VC-PAB.

General Information

Category
ADCs Cytotoxin with Linkers
Product Name
Mal-VC-PAB-ABAEP-Azonafide
CAS
2259318-48-2
Catalog Number
BADC-00669
Molecular Formula
C61H71N11O12
Molecular Weight
1150.28

Chemical Structure

  • Mal-VC-PAB-ABAEP-Azonafide
Canonical SMILES
O=C(N1CCN2CCN(CCNC(C3=CC=C(NC(OCC4=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN5C(C=CC5=O)=O)=O)=O)=O)C=C4)=O)C=C3)=O)CC2)C6=C7C(C(OC)=CC=C7C1=O)=CC8=CC=CC=C68
1.ROR1 ANTIBODY IMMUNOCONJUGATES
LANNUTTI, Brian, et al.
Cancer is the second leading cause of human death next to coronary artery disease.Receptor tyrosine kinases (RTKs) play a key role in oncogenic transformation, growth andmetastases. RTKs regulate cell differentiation, proliferation, migration, angiogenesis, andsurvival. The receptor tyrosine kinase-like orphan receptor 1 (ROR1) is an evolutionarilyconserved type I membrane protein that belongs to the ROR subfamily and has extracellulardomains that contain immunoglobulin (Ig)-like, Frizzled, and Kringle domains. ROR 1-deficientmice display a variety of phenotypic defects within the skeletal and urogenital systems, as wellas postnatal growth retardation. ROR1 is expressed during embryogenesis and by a variety ofdifferent cancers, but not by normal post-partum tissues, and can be considered an oncoembryonic surface antigen. Functional data suggest that ROR1 may function in non-canonicalWNT-signaling to promote the survival of malignant cells.

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