Name: Mal-amido-PEG2-Val-Cit-PAB-PNP
Brand: BOC Sciences
Rating: 5 (1 reviews)

Synonyms

4-((2S,5S)-19-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5-isopropyl-4,7,17-trioxo-2-(3-ureidopropyl)-10,13-dioxa-3,6,16-triazanonadecanamido)benzyl (4-nitrophenyl) carbonate

IUPAC Name

Canonical SMILES

CC(C)C(C(=O)NC(CCCNC(=O)N)C(=O)NC1=CC=C(C=C1)COC(=O)OC2=CC=C(C=C2)[N+](=O)[O-])NC(=O)CCOCCOCCNC(=O)CCN3C(=O)C=CC3=O

InChI

InChI=1S/C39H50N8O14/c1-25(2)35(45-32(49)16-20-58-22-23-59-21-18-41-31(48)15-19-46-33(50)13-14-34(46)51)37(53)44-30(4-3-17-42-38(40)54)36(52)43-27-7-5-26(6-8-27)24-60-39(55)61-29-11-9-28(10-12-29)47(56)57/h5-14,25,30,35H,3-4,15-24H2,1-2H3,(H,41,48)(H,43,52)(H,44,53)(H,45,49)(H3,40,42,54)/t30-,35-/m0/s1

InChIKey

PAGAOQLHMRBQFV-QGRQJHSQSA-N

Solubility

10 mm in DMSO

Shelf Life

0-4°C for short term (days to weeks), or -20°C for long term (months).

Shipping

Room temperature, or blue ice upon request.

Storage

Store at -20 °C, keep in dry and avoid sunlight.

Mal-amido-PEG2-Val-Cit-PAB-PNP, a versatile linker molecule used in drug delivery and bioconjugation, plays a pivotal role in various applications.

Antibody-Drug Conjugates (ADCs): Mal-amido-PEG2-Val-Cit-PAB-PNP serves as a crucial link in the synthesis of antibody-drug conjugates. This linkage between a cytotoxic drug and an antibody ensures site-specific drug release at the tumor, minimizing systemic toxicity while maximizing therapeutic efficacy.

Controlled Drug Release: Enabling the design of advanced drug delivery systems, Mal-amido-PEG2-Val-Cit-PAB-PNP linkers provide a sophisticated approach to controlled drug release triggered by specific stimuli such as pH variations or enzymatic activity. The Val-Cit peptide sequence, susceptible to tissue-specific enzymes, allows for precise and controlled drug release at designated sites. This method enhances therapeutic efficacy while mitigating adverse effects, optimizing drug delivery for improved patient outcomes.

Pharmaceutical Research: A cornerstone of pharmaceutical research, this linker molecule facilitates exploration into the design and enhancement of drug delivery systems. Researchers leverage its flexibility to adjust properties by modifying PEG length or integrating additional functional groups, tailoring the linker for diverse therapeutic applications. This strategic customization enhances pharmacokinetic profiles and bolsters the stability of therapeutic agents, driving innovation in pharmaceutical sciences and advancing drug delivery technologies.

Catalog	Product Name	CAS
BADC-01679	Mal-PEG2-Val-Cit-PABA-PNP	1345681-52-8
BADC-00929	Fmoc-D-Val-Cit-PAB	1350456-65-3
BADC-00849	Acetylene-linker-Val-Cit-PABC-MMAE	1411977-95-1
BADC-01448	mDPR-Val-Cit-PAB-MMAE	1491152-26-1
BADC-00958	Amino-PEG4-Val-Cit-PAB-MMAE	1492056-71-9
BADC-00708	Val-cit-PAB-OH	159857-79-1
BADC-00968	MC-Val-Cit-PAB	159857-80-4
BADC-00501	Mc-Val-Cit-PABC-PNP	159857-81-5
BADC-00364	Fmoc-Val-Cit-PAB	159858-22-7
BADC-01348	Val-Cit-PAB-MMAE TFA salt	1608127-32-7