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CAS No.: 2378428-21-6
Cat No.: BADC-01517
4.5 
MP-PEG4-VK(Boc)G-OSu is a biomedical chemical widely used in the biomedical industry. As a structurally modified polyethylene glycol (PEG) compound, it demonstrates the incorporation of VK(Boc)G-OSu functional groups, revolutionizing drug conjugation and targeted drug delivery systems.
Structure of 2378428-21-6
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MP-PEG4-VK(Boc)G-OSu, a cutting-edge chemical compound in bioconjugation and drug development, offers a plethora of applications.
Bioconjugation: MP-PEG4-VK(Boc)G-OSu serves as a versatile instrument for conjugating proteins, peptides, and a myriad of biomolecules. Featuring an N-hydroxysuccinimide (NHS) ester group, it facilitates the formation of stable amide bonds with primary amines, a prevalent feature in proteins and peptides. This modification not only enhances the solubility and stability of the conjugated entities but also augments their bioavailability, unveiling novel avenues for research and development.
Drug Delivery Systems: Spearheading innovation in drug delivery, MP-PEG4-VK(Boc)G-OSu assumes a pivotal role in crafting sophisticated delivery systems. It is harnessed to append polyethylene glycol (PEG) chains to therapeutic molecules through PEGylation. This alteration amplifies the pharmacokinetics of drugs by mitigating immunogenicity and prolonging circulation time in the bloodstream.
Material Science: Within the realm of material science, MP-PEG4-VK(Boc)G-OSu finds utility in surface and nanoparticle functionalization, modifying their properties. This contribution bolsters biocompatibility and averts nonspecific binding in biomedical tools and diagnostic assays. The compound's role in augmenting the performance of medical implants and biosensors via surface enhancements underscores its significance in propelling healthcare technologies and elevating patient outcomes.
Proteomics Research: In the dynamic landscape of proteomics, MP-PEG4-VK(Boc)G-OSu emerges as an indispensable asset for labeling proteins in diverse analytical methodologies, including mass spectrometry. Its distinct functional groups enable precise tagging, facilitating specific identification and quantification of proteins within complex mixtures.
| Catalog | Product Name | CAS | Inquiry |
|---|---|---|---|
| BADC-01491 | MP-PEG8-VA-PABC | 1938099-52-5 | |
| BADC-01451 | MP-PEG4-Val-Lys-Gly-7-MAD-MDCPT | 2378428-19-2 |
What is MP-PEG4-VK(Boc)G-OSu and its role in ADC synthesis?
MP-PEG4-VK(Boc)G-OSu is a bifunctional linker featuring an N-hydroxysuccinimide ester for amine coupling and a Boc-protected lysine for controlled conjugation. It enables precise antibody modification and payload attachment while maintaining structural stability during synthesis.
7/9/2022
Could you advise how Boc protection influences conjugation?
The Boc group temporarily blocks the lysine side chain, preventing undesired reactions during initial conjugation steps. It can be selectively removed under acidic conditions to expose the amine for further functionalization, ensuring controlled ADC assembly.
29/7/2019
We are interested in which payloads are suitable for MP-PEG4-VK(Boc)G-OSu.
This linker is compatible with payloads containing primary amines for OSu-mediated coupling. The PEG spacer improves solubility and reduces steric hindrance, allowing efficient attachment of cytotoxins, fluorescent dyes, or other functional molecules.
17/4/2019
Good morning! Could you please advise the handling and storage recommendations for MP-PEG4-VK(Boc)G-OSu?
Store at low temperatures in a dry, inert environment to prevent hydrolysis of the OSu ester. Avoid prolonged exposure to moisture and acids to maintain Boc protection and overall linker stability prior to conjugation.
13/6/2019
Good morning! How should MP-PEG4-VK(Boc)G-OSu be stored to preserve its reactivity for peptide conjugation?
MP-PEG4-VK(Boc)G-OSu is best stored at -20°C under desiccated conditions. Exposure to moisture should be minimized. It is recommended to aliquot the product for single-use applications, which prevents repeated opening and reduces the risk of degradation that could impact conjugation efficiency.
2/7/2018
— Dr. James Parker, Senior Scientist (UK)
MP-PEG4-VK(Boc)G-OSu demonstrated excellent reactivity and reliable coupling in our linker synthesis.
17/4/2019
— Ms. Claudia Weber, Biochemist (Germany)
Batch-to-batch consistency was impressive, enabling reproducible ADC constructs.
2/7/2018
— Dr. Sophie Martin, Medicinal Chemist (France)
The Boc protection remained stable under all reaction conditions, ensuring product integrity.
13/6/2019
— Dr. Ethan White, ADC Scientist (USA)
High yields and minimal side products were achieved consistently.
7/9/2022
— Dr. Helena Fischer, Research Scientist (Germany)
This reagent allowed us to explore new linker designs for improved pharmacokinetics.
— Ms. Isabella Rossi, Peptide Chemist (Italy)
MP-PEG4-VK(Boc)G-OSu supplied by BOC Sciences allowed smooth peptide linker synthesis with high coupling efficiency and minimal by-products.
29/7/2019
MP-PEG4-VK(Boc)G-OSu
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MP-PEG4-VK(Boc)G-OSu
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