Name: Boc-Val-Ala-PAB
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Synonyms

tert-Butyl ((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate; (S)-2-(Boc-amino)-N-[(S)-1-[[4-(hydroxymethyl)phenyl]amino]-1-oxo-2-propyl]-3-methylbutanamide

IUPAC Name

tert-butyl N-[(2S)-1-[[(2S)-1-[4-(hydroxymethyl)anilino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate

Canonical SMILES

CC(C)C(C(=O)NC(C)C(=O)NC1=CC=C(C=C1)CO)NC(=O)OC(C)(C)C

InChI

InChI=1S/C20H31N3O5/c1-12(2)16(23-19(27)28-20(4,5)6)18(26)21-13(3)17(25)22-15-9-7-14(11-24)8-10-15/h7-10,12-13,16,24H,11H2,1-6H3,(H,21,26)(H,22,25)(H,23,27)/t13-,16-/m0/s1

InChIKey

AWZITSKTOAURSJ-BBRMVZONSA-N

Density

1.166±0.06 g/cm3

Appearance

White to Off-white Solid

Boiling Point

653.7±55.0 °C at 760 mmHg

Boc-Val-Ala-PAB, a synthetic molecule commonly applied in peptide synthesis and drug delivery, carries significant importance in various fields.

Peptide Synthesis: A pivotal component in synthesizing peptides, Boc-Val-Ala-PAB serves as a crucial building block. Acting as a shield for amino acids, it safeguards against unwanted reactions during peptide assembly, ensuring the purity and yield vital for subsequent research and therapeutic usage. This protective role plays a critical part in the synthesis process, guaranteeing the integrity of the peptides formed.

Drug Delivery Systems: Within drug delivery systems, Boc-Val-Ala-PAB plays a dual role in enhancing stability and amplifying the effectiveness of therapeutic compounds. Its integration into prodrugs acts as a shield, safeguarding the active pharmaceutical ingredient until it reaches its intended destination. This integration not only enhances bioavailability but also diminishes the adverse effects associated with medications, offering a more targeted and efficient treatment approach.

Protease Substrate Design: In the realm of studying protease activity, Boc-Val-Ala-PAB plays a pivotal role in substrate design. With a specific sequence tailored for recognition and cleavage by select proteases, it proves invaluable in biochemical assays. This application stands as a cornerstone in unraveling protease functionalities and lays the groundwork for the development of protease inhibitors with potential as pharmaceutical candidates, showcasing its multifaceted utility in research and drug development.

Anticancer Research: Researchers leverage Boc-Val-Ala-PAB as a fundamental linker in crafting antibody-drug conjugates (ADCs). These conjugates fuse antibody-targeting precision with small molecule cytotoxicity, facilitating targeted delivery of anticancer agents specifically to tumor cells. By facilitating controlled drug release, Boc-Val-Ala-PAB maximizes therapeutic efficacy while simultaneously minimizing harm to healthy tissues, underscoring its pivotal role in cutting-edge anticancer research and treatment innovations.