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Aminooxy-PEG2-BCN is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-01663 | -- | $-- | Inquiry |
Aminooxy-PEG2-BCN is a bifunctional linker used in bioconjugation and chemical biology studies. Here are some key applications of Aminooxy-PEG2-BCN:
Site-Specific Protein Labeling: Aminooxy-PEG2-BCN is instrumental in site-specific labeling of proteins through oxime ligation. By targeting aldehyde or ketone functional groups on proteins, this linker facilitates the attachment of probes or therapeutic molecules. This enables highly specific molecular studies and targeted drug delivery.
Antibody-Drug Conjugates: This linker is employed in the development of antibody-drug conjugates (ADCs), which are targeted cancer therapies that combine an antibody specific to cancer cells with a cytotoxic drug. Aminooxy-PEG2-BCN allows the efficient and stable conjugation of the drug to the antibody. This results in targeted delivery of the drug to cancer cells while minimizing off-target effects.
Biomaterial Functionalization: Aminooxy-PEG2-BCN is used to functionalize surfaces of biomaterials for various biomedical applications. By attaching specific biomolecules to the surface of implants or tissue engineering scaffolds, it enhances biocompatibility and interacts with biological tissues. This promotes improved integration and functionality in medical devices.
Chemical Biology Probes: Researchers use Aminooxy-PEG2-BCN to develop chemical biology probes for studying cellular processes and molecular interactions. Its ability to form stable conjugates with various biomolecules allows for the design of specialized probes. This facilitates the exploration of complex biological pathways and aids in drug discovery research.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
