Aminooxy-PEG2-BCN

Aminooxy-PEG2-BCN is a bifunctional linker used in bioconjugation and chemical biology studies. Here are some key applications of Aminooxy-PEG2-BCN:

Site-Specific Protein Labeling: Aminooxy-PEG2-BCN is instrumental in site-specific labeling of proteins through oxime ligation. By targeting aldehyde or ketone functional groups on proteins, this linker facilitates the attachment of probes or therapeutic molecules. This enables highly specific molecular studies and targeted drug delivery.

Antibody-Drug Conjugates: This linker is employed in the development of antibody-drug conjugates (ADCs), which are targeted cancer therapies that combine an antibody specific to cancer cells with a cytotoxic drug. Aminooxy-PEG2-BCN allows the efficient and stable conjugation of the drug to the antibody. This results in targeted delivery of the drug to cancer cells while minimizing off-target effects.

Biomaterial Functionalization: Aminooxy-PEG2-BCN is used to functionalize surfaces of biomaterials for various biomedical applications. By attaching specific biomolecules to the surface of implants or tissue engineering scaffolds, it enhances biocompatibility and interacts with biological tissues. This promotes improved integration and functionality in medical devices.

Chemical Biology Probes: Researchers use Aminooxy-PEG2-BCN to develop chemical biology probes for studying cellular processes and molecular interactions. Its ability to form stable conjugates with various biomolecules allows for the design of specialized probes. This facilitates the exploration of complex biological pathways and aids in drug discovery research.