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N,N-Bis(PEG2-N3)-N-amido-PEG2-thiol is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-01296 | -- | $-- | Inquiry |
N,N-Bis(PEG2-N3)-N-amido-PEG2-thiol, a versatile molecule with diverse biomedical and chemical applications, is a cornerstone in various cutting-edge fields.
Bioconjugation: This compound serves as a linchpin in bioconjugation techniques, enabling the fusion of biomolecules to surfaces, nanoparticles, or other molecular entities. The presence of azide groups facilitates “click chemistry” reactions, facilitating the attachment of intricate biomolecules like proteins or DNA. This process is indispensable in crafting advanced drug delivery systems, diagnostics, and the evolution of biosensors.
Drug Delivery: N,N-Bis(PEG2-N3)-N-amido-PEG2-thiol plays a pivotal role in enhancing the stability and solubility of pharmaceutical agents, elevating drug delivery applications to new heights. The thiol group acts as an anchor, binding drugs to gold nanoparticles or alternative carriers, which can then be tailored using PEGylation to extend circulation time within the body. This innovative strategy is particularly crucial in delivering anticancer medications and biologics with minimized side effects.
Protein Modification: In the realm of protein engineering, this compound shines as a catalyst for site-specific protein modification, empowering researchers to affix chemical groups or fluorophores to proteins with precision. The azide groups offer a gateway to meticulous modifications through interactions with alkyne-functionalized tags, preserving protein activity. This application is vital for scrutinizing protein dynamics, interactions, and functions within intricate biochemical pathways, shedding light on the intricate world of biomolecular processes.
Surface Functionalization: Harnessing the power of N,N-Bis(PEG2-N3)-N-amido-PEG2-thiol, researchers can revolutionize the landscape of surface functionalization in microarray and biosensor technologies. The thiol group’s binding prowess allows for adhesion to metal surfaces like gold, establishing a foundation for subsequent modification with biomolecules.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
