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CAS No.: 629-13-0
Cat No.: BADC-01528
4.5 
Azide-C2-Azide is a bioorthogonal conjugation building block that provides an azide handle for modular click-chemistry workflows. The molecule can be used to introduce a click-reactive group onto an antibody, peptide, linker intermediate, or payload-containing component, depending on the chemistry of its second terminal functionality. Its additional reactive group is azide bioorthogonal handle; requires complementary click handle on the antibody. Conjugation can be performed using spaac with dbco/bcn-functionalized partner or cuaac with terminal alkyne partner, depending the complementary handle. The sequence and orientation of the coupling steps should be selected according to the functional groups carried by the two conjugation partners.
Structure of 629-13-0
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Azide-C2-Azide, a multifaceted bifunctional linker, boasts a wide array of applications in chemical biology and materials science. Dive into the realm of Azide-C2-Azide with four high-perplexity, bursty applications:
Bioorthogonal Chemistry: Anchored in the foundation of modern bioorthogonal chemistry, Azide-C2-Azide plays a pivotal role in orchestrating bioorthogonal click chemistry reactions, most notably the copper-catalyzed azide-alkyne cycloaddition (CuAAC). This compound facilitates the precise and effective labeling of biomolecules within intricate biological systems without perturbing natural processes. Scientists harness this capability to mark and track proteins, nucleic acids, and other biomolecules with exceptional precision, ushering in novel avenues for molecular exploration.
Drug Delivery Systems: Spearheading drug delivery innovations, Azide-C2-Azide empowers the creation of intricate drug delivery systems by enabling the conjugation of therapeutic compounds to drug carriers. This bifunctional linker opens doors for coupling drugs to nanoparticles, liposomes, or other delivery platforms through click chemistry, enhancing targeted drug delivery and controlled release mechanisms.
Material Science: Within the domain of material science, Azide-C2-Azide stands out as a pivotal element in crafting functionalized polymers and surface coatings. By integrating azide groups into polymer structures or surface layers, scientists leverage click chemistry to affix diverse functional moieties, such as fluorescent tags or bioactive molecules. This methodical technique plays a vital role in formulating advanced materials with customizable properties, catering to applications in biotechnology and nanotechnology with unparalleled adaptability.
Proteomics: Navigating the intricate landscape of proteomics, Azide-C2-Azide emerges as a valuable tool for protein identification and characterization. By utilizing azide-functionalized probes to label proteins, researchers conduct pull-down assays and mass spectrometry analyses, shedding light on protein-protein interactions, post-translational modifications, and overall protein dynamics across diverse cellular contexts.
Azide-C2-Azide
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Azide-C2-Azide
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