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DSG is a membrane-permeable and non-cleavable crosslinker, allowing for intracellular labeling of peptides and proteins.
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-01162 | -- | $-- | Inquiry |
DSG Crosslinker, a versatile chemical reagent integral to bioconjugation and biomolecular research, finds diverse applications across various domains. Here are four key applications:
Protein-Protein Interaction Studies: A commonly utilized tool, DSG Crosslinker plays a pivotal role in stabilizing and investigating protein-protein interactions. Through covalent bonding of interacting protein pairs, researchers can seize and scrutinize transient complexes that pose challenges in conventional study methodologies. This approach illuminates the dynamic nature and functional nuances of protein assemblies entwined in diverse biological phenomena.
Structural Biology: Within the realm of structural biology, DSG Crosslinker serves as a catalyst for exploring protein structures and conformations. By strategically linking sites within a protein or between protein subunits, scientists can unveil distance constraints pivotal in modeling and validating intricate three-dimensional structures. This methodological advancement proves invaluable in unraveling the convoluted architecture of biomolecular machinery.
Antibody Conjugation: Embraced widely in antibody conjugation endeavors for diagnostic and therapeutic ventures, DSG Crosslinker facilitates the linkage of antibodies to fluorophores, enzymes, or therapeutic agents. Through this strategic conjugation, researchers and healthcare practitioners fabricate precision tools tailored for imaging, detection, or disease intervention. This precision-enhancing strategy amplifies the specificity and efficacy of diagnostic assays and therapeutic modalities significantly.
Enzyme and Receptor Studies: Instrumental in the scrutiny of enzymes and receptors, DSG Crosslinker emerges as a critical agent in stabilizing and characterizing functional complexes. By crosslinking enzymes to their substrates or receptors to their interacting ligands, researchers unearth detailed insights into binding affinities, kinetics, and mechanistic underpinnings. This profound comprehension holds pivotal significance in the realms of drug discovery and unraveling the intricate pathways underpinning biochemical cascades.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
