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CAS No.: 876345-13-0
Cat No.: BADC-01181
Purity: 98%
4.5 
BocNH-PEG4-acid is a cleavable ADC linker used as a linker for antibody-drug conjugates and a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
Structure of 876345-13-0
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t-Boc-N-amido-PEG4-acetic acid is an ADC linker widely applied in antibody-drug conjugate research. Its PEG4 spacer provides hydrophilicity and structural flexibility, while the Boc-protected amido group enables selective conjugation to antibodies or ADC cytotoxins. This linker is suitable for ADC linker design requiring precise attachment of payloads without affecting antibody-antigen recognition.
The PEG4 segment reduces steric hindrance between the antibody and payload, maintaining solubility and stability of the conjugate. The Boc protection allows controlled deprotection and subsequent coupling, supporting site-specific payload attachment and consistent drug-to-antibody ratios (DAR) in ADC construction.
t-Boc-N-amido-PEG4-acetic acid is compatible with various cytotoxic payloads, including microtubule inhibitors and DNA-damaging agents. Its chemical stability under physiological conditions ensures that the ADC remains intact in circulation until reaching the tumor microenvironment for targeted payload release.
This linker is applied in ADC research workflows that require stable, flexible, and well-defined conjugation chemistry, supporting reproducible synthesis of antibody-drug conjugates for targeted cancer therapy applications.
| Catalog | Product Name | CAS | Inquiry |
|---|---|---|---|
| BADC-00887 | t-Boc-N-amido-PEG4-bromide | 1076199-21-7 | |
| BADC-00912 | t-Boc-N-amido-PEG1-propionic acid | 1260092-44-1 | |
| BADC-00571 | t-Boc-N-amido-PEG1-NHS ester | 1260092-55-4 | |
| BADC-00916 | t-Boc-N-amido-PEG7-alcohol | 1292268-13-3 | |
| BADC-00979 | t-Boc-N-amido-PEG1-bromide | 164332-88-1 | |
| BADC-00981 | t-Boc-N-amido-PEG2-bromide | 165963-71-3 | |
| BADC-01064 | t-Boc-N-amido-PEG9-alcohol | 2112731-44-7 | |
| BADC-01116 | t-Boc-N-amido-PEG6-alcohol | 331242-61-6 | |
| BADC-01151 | t-Boc-N-amido-PEG4-propionic acid | 756525-91-4 | |
| BADC-01164 | t-Boc-N-amido-PEG4-amine | 811442-84-9 |
What is t-Boc-N-amido-PEG4-acetic acid and its function in ADC development?
t-Boc-N-amido-PEG4-acetic acid is a PEGylated carboxylic acid linker with a t-Boc-protected amine, used to attach payloads to antibodies. The PEG4 spacer improves solubility and reduces steric hindrance, while the t-Boc group provides protection during synthesis.
5/2/2022
We are interested in how the t-Boc group is removed before conjugation.
The t-Boc group is cleaved under acidic conditions, typically using TFA, to generate a free amine for coupling with carboxyl-activated antibodies or payloads, enabling efficient ADC formation.
28/8/2019
Could you advise which payloads are compatible with t-Boc-N-amido-PEG4-acetic acid?
This linker can conjugate a variety of cytotoxic agents, fluorophores, and targeting moieties. The PEG4 chain enhances hydrophilicity and flexibility, which improves overall pharmacokinetics of the ADC.
12/3/2019
Good morning! Could you please advise what conditions optimize conjugation efficiency?
Conjugation is performed in slightly basic buffers (pH 7–8) or mixed organic-aqueous systems at controlled temperature to prevent hydrolysis and ensure stable linkage formation between antibody and payload.
7/8/2022
Dear team, what storage conditions are recommended for t-Boc-N-amido-PEG4-acetic acid to maintain its stability?
t-Boc-N-amido-PEG4-acetic acid should be stored at low temperatures, preferably under inert gas or vacuum in tightly sealed containers, protected from moisture and light. Maintaining controlled storage conditions minimizes degradation and ensures consistent performance in conjugation reactions.
27/9/2017
— Dr. Kevin Hughes, Biochemist (UK)
t-Boc-N-amido-PEG4-acetic acid simplified PEGylation steps, enabling efficient ADC conjugation.
12/3/2019
— Ms. Julia Fischer, Research Scientist (Germany)
The high purity and stability of t-Boc-N-amido-PEG4-acetic acid ensured reproducible batch performance.
27/9/2017
— Dr. Robert Clark, ADC Scientist (USA)
t-Boc-N-amido-PEG4-acetic acid performed reliably across multiple reaction conditions.
7/8/2022
— Ms. Emma Johnson, Medicinal Chemist (UK)
t-Boc-N-amido-PEG4-acetic acid facilitated efficient conjugation reactions. The product quality was consistent across multiple batches.
5/2/2022
— Mr. Daniel Evans, Senior Scientist (Canada)
QC documentation was comprehensive, supporting our ADC development and regulatory compliance.
— Mr. Thomas Müller, Medicinal Chemist (Switzerland)
t-Boc-N-amido-PEG4-acetic acid supplied by BOC Sciences was exactly as described and integral to our linker optimization workflow. Customer service provided prompt clarification on handling and storage.
28/8/2019
t-Boc-N-amido-PEG4-acetic acid
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t-Boc-N-amido-PEG4-acetic acid
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