Fmoc-L-Lys(Pentynoyl-DIM)-OH - CAS 2408993-33-7 Catalog number: BADC-01848

Fmoc-L-Lys(Pentynoyl-DIM)-OH, a modified amino acid utilized in peptide synthesis, boasts diverse applications in biochemistry and molecular biology. Here are four key applications:

Peptide Synthesis: In solid-phase peptide synthesis, Fmoc-L-Lys(Pentynoyl-DIM)-OH plays a pivotal role in incorporating modified lysine residues. These alterations introduce unique chemical functionalities that can enhance the stability, activity, or specificity of synthetic peptides.

Drug Development: Within the realm of drug development, modified amino acids like Fmoc-L-Lys(Pentynoyl-DIM)-OH are harnessed to formulate peptide-based drugs with enhanced pharmacokinetic profiles. By integrating this modified lysine into a peptide chain, resistance to proteolytic degradation is bolstered, extending the peptide’s longevity in the body.

Protein Engineering: Delving into protein engineering, Fmoc-L-Lys(Pentynoyl-DIM)-OH emerges as a tool for introducing site-specific modifications into proteins. This technique empowers researchers to probe protein structure and function by integrating chemically distinct amino acids at precise loci. Such alterations can facilitate the tracking of protein interactions, manipulation of enzyme activity, or simplification of protein labeling processes, unlocking new frontiers in biotechnological research.

Bioconjugation: The pentynoyl group within Fmoc-L-Lys(Pentynoyl-DIM)-OH enables selective biomolecular attachment via click chemistry reactions. This attribute proves exceptionally useful for affixing fluorescent markers, drugs, or other probes to peptides and proteins. Bioconjugation techniques leveraging this compound elevate the exploration of biological processes and the refinement of bioanalytical tools, offering a glimpse into the intricacies of molecular interactions.