Fmoc-L-Lys(4-N3-Z)-OH - CAS 1446511-14-3 Catalog number: BADC-01725

Fmoc-L-Lys(4-N3-Z)-OH, a specialized reagent utilized in peptide synthesis and bioconjugation studies, possesses diverse applications in the realm of chemical biology. Here are four key applications:

Peptide Synthesis: Serving as a fundamental component in solid-phase peptide synthesis, Fmoc-L-Lys(4-N3-Z)-OH plays a pivotal role in crafting peptides with tailored functionalities for varied research and therapeutic purposes. The presence of an azide group enables subsequent post-synthetic functionalization through click chemistry methodologies, allowing for the creation of custom peptides with specific attributes and functionalities that cater to unique applications in the field.

Site-Specific Labeling: Leveraging the azide group inherent in Fmoc-L-Lys(4-N3-Z)-OH, researchers can achieve precise and targeted labeling of peptides and proteins through bioorthogonal click reactions, such as the azide-alkyne cycloaddition. This innovative approach facilitates the attachment of fluorescent tags, probes, or other biomolecules to peptides and proteins, enabling the exploration of intricate protein interactions and dynamics with a high level of specificity and accuracy.

Bioconjugation: In the realm of bioconjugation techniques, Fmoc-L-Lys(4-N3-Z)-OH facilitates the covalent linking of proteins and biomolecules through the versatile azide functionality. This feature serves as a convenient handle for conjugating a diverse array of molecules, including drugs, nanoparticles, and polymers, thereby playing a crucial role in the development of targeted drug delivery systems and advanced biomaterials that hold potential for groundbreaking advances in the field of biomedicine.

Chemical Biology: The azide-protected lysine derivative offers a gateway to introducing azide functionalities into peptides and proteins, enabling their utilization in chemical biology applications. These azide-modified biomolecules can actively engage in click chemistry reactions, shedding light on protein functions and interactions within the intricate cellular milieu.