Fmoc-L-Lys(N3-Aca-DIM)-OH - CAS 2408993-39-3

Fmoc-L-Lys(N3-Aca-DIM)-OH - CAS 2408993-39-3 Catalog number: BADC-01840

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Fmoc-L-Lys(N3-Aca-DIM)-OH is a click chemistry reagent containing an azide group.

Category
ADCs Linker
Product Name
Fmoc-L-Lys(N3-Aca-DIM)-OH
CAS
2408993-39-3
Catalog Number
BADC-01840
Molecular Formula
C35H43N5O6
Molecular Weight
629.75

Ordering Information

Catalog Number Size Price Quantity
BADC-01840 -- $-- Inquiry
Description
Fmoc-L-Lys(N3-Aca-DIM)-OH is a click chemistry reagent containing an azide group.
Synonyms
N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-epsilon-[6-azido-1-(4,4-dimethyl-2,6-dioxocyclohexylidene)hexyl]-L-lysine
IUPAC Name
(2S)-6-[[6-azido-1-(2-hydroxy-4,4-dimethyl-6-oxocyclohexen-1-yl)hexylidene]amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid
Canonical SMILES
CC1(CC(=C(C(=O)C1)C(=NCCCCC(C(=O)O)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24)CCCCCN=[N+]=[N-])O)C
InChI
InChI=1S/C35H43N5O6/c1-35(2)20-30(41)32(31(42)21-35)28(16-4-3-10-19-38-40-36)37-18-11-9-17-29(33(43)44)39-34(45)46-22-27-25-14-7-5-12-23(25)24-13-6-8-15-26(24)27/h5-8,12-15,27,29,41H,3-4,9-11,16-22H2,1-2H3,(H,39,45)(H,43,44)/t29-/m0/s1
InChIKey
BFEOBKQXWBSIEV-LJAQVGFWSA-N

Fmoc-L-Lys(N3-Aca-DIM)-OH is a specialized amino acid derivative used in peptide synthesis and other advanced biochemical applications. Here are some key applications of Fmoc-L-Lys(N3-Aca-DIM)-OH:

Peptide Synthesis: Fmoc-L-Lys(N3-Aca-DIM)-OH is utilized in solid-phase peptide synthesis to introduce lysine residues with specific functional groups. This allows for the design and synthesis of custom peptides with unique properties such as enhanced binding affinity or stability. Such peptides are valuable in drug development, structural biology, and therapeutic research.

Chemical Biology: In chemical biology, this amino acid derivative is used to create bioconjugates and modified proteins. The presence of the azido group (N3) enables bioorthogonal click chemistry reactions, allowing the attachment of various probes, tags, or other functional groups. This facilitates the tracking, imaging, and functional analysis of proteins in biological systems.

Targeted Drug Delivery: Fmoc-L-Lys(N3-Aca-DIM)-OH can be incorporated into peptide-based drug delivery systems to enhance specificity and efficacy. By conjugating therapeutic agents to peptides containing this derivative, researchers can develop targeted delivery systems that release drugs in response to specific cellular environments or stimuli. This approach improves the precision and reduces the side effects of treatments.

Antimicrobial Peptide Design: This specialized amino acid derivative is used in the design of antimicrobial peptides (AMPs) with improved activity and selectivity. By modifying the lysine residue through azido and dimethylamino groups, researchers can enhance the interaction of AMPs with microbial membranes. This leads to the development of potent and selective antimicrobial agents for treating bacterial infections.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Historical Records: Fmoc-L-Lys(N3-Aca-DIM)-OH
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