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Boc-L-Tyr(PEG(3)-N3)-OH (DCHA)

  CAS No.:   Cat No.: BADC-01881 4.5  

Boc-L-Tyr(PEG(3)-N3)-OH (DCHA) is an azide-functionalized tyrosine ADC linker with PEG3 spacer and Boc protection, enhancing solubility, stability, and site-specific conjugation for targeted payload delivery. Keywords: ADC linker, azide linker, PEG spacer, tyrosine derivative, click chemistry.

Boc-L-Tyr(PEG(3)-N3)-OH (DCHA)

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ADC Linker
Molecular Formula
C32H53N5O7
Molecular Weight
619.79

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Boc-L-Tyr(PEG(3)-N3)-OH (DCHA), a versatile chemical in the realm of bioscience, holds diverse applications. Here are four key applications:

Chemical Conjugation Studies: Serving as a pivotal player in bioconjugation reactions, Boc-L-Tyr(PEG(3)-N3)-OH (DCHA) boasts an azide functional group tailored for engaging in click chemistry interactions. This unique characteristic positions it ideally for linking biomolecules such as peptides, proteins, and nucleic acids to a myriad of substrates. These applications play an indispensable role in the genesis of biomarkers, diagnostics, and therapeutic agents, propelling the boundaries of biochemistry into uncharted realms of innovation.

Drug Delivery Systems: With its integral polyethylene glycol (PEG) component, Boc-L-Tyr(PEG(3)-N3)-OH (DCHA) emerges as a crucial asset in constructing cutting-edge drug delivery systems. The PEG moiety enhances drug solubility and stability, while the azide group facilitates seamless conjugation with drug molecules or targeting ligands. This fusion elevates the pharmacokinetic attributes and targeted delivery of therapeutic agents.

Protein and Peptide Modification: Embracing Boc-L-Tyr(PEG(3)-N3)-OH (DCHA) for protein and peptide modification amplifies their therapeutic efficacy to new heights. The PEGylation process mitigates immunogenic responses and prolongs the half-life of these bioagents in circulation. Moreover, the azide group streamlines site-specific conjugation, a critical element in preserving biological activity. This transformative approach holds immense promise in advancing the realm of personalized medicine towards tailored treatments and improved patient outcomes.

Surface Functionalization: In the dynamic arenas of material science and surface chemistry, Boc-L-Tyr(PEG(3)-N3)-OH (DCHA) steps in as a key player in adorning surfaces with bioactive entities. This intervention plays a pivotal role in crafting biocompatible coatings on medical devices, biosensors, and implants. By imbuing surfaces with biomolecules, it enhances cellular adhesion, proliferation, and overall biocompatibility, fostering seamless integration and optimal functionality within intricate biological environments. This innovative approach reshapes the landscape of surface engineering and biofunctionalization, unlocking new possibilities in biotechnology and healthcare advancements.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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