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Azidoethyl-SS-ethylamine

  CAS No.: 1807512-40-8   Cat No.: BADC-01000   Purity: >98.0% 4.5  

Azidoethyl-SS-ethylamine is a bifunctional ADC linker featuring azide and amine groups with a cleavable disulfide bond, supporting site-specific conjugation and controlled intracellular drug release.

Azidoethyl-SS-ethylamine

Structure of 1807512-40-8

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Category
ADC Linker
Molecular Formula
C4H10N4S2
Molecular Weight
178.28
Shipping
Room temperature, or blue ice upon request.
Shipping
Store at 4 °C

* For research and manufacturing use only. We do not sell to patients.

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Popular Publications Citing BOC Sciences Products
Synonyms
2-((2-azidoethyl)disulfanyl)ethan-1-amine; 2-(2-azidoethyldisulfanyl)ethanamine
IUPAC Name
Canonical SMILES
C(CSSCCN=[N+]=[N-])N
InChI
InChI=1S/C4H10N4S2/c5-1-3-9-10-4-2-7-8-6/h1-5H2
InChIKey
OCLWTYKOHAVGIZ-UHFFFAOYSA-N
Solubility
10 mm in DMSO
Appearance
Solid
Shelf Life
0-4°C for short term (days to weeks), or -20°C for long term (months).
Shipping
Room temperature, or blue ice upon request.
Storage
Store at 4 °C
Form
Solid

Azidoethyl-SS-ethylamine is a versatile compound commonly used in chemical and biological research for various applications. Here are some key applications of Azidoethyl-SS-ethylamine:

Bioconjugation: Azidoethyl-SS-ethylamine is often employed in bioconjugation techniques to link biomolecules such as proteins, peptides, and nucleic acids with other moieties like fluorescent dyes or affinity tags. It achieves this through click chemistry, facilitating efficient and specific covalent bonding under mild conditions. This enables researchers to create highly defined and functionalized biomolecular assemblies for use in diagnostics and therapeutic research.

Chemical Biology: In chemical biology, Azidoethyl-SS-ethylamine serves as a reagent for the synthesis of complex molecules. Its azido functional group is pivotal for click reactions, allowing for the construction of diverse compound libraries. These libraries are essential for screening potential drug candidates and studying biological interactions at a molecular level.

Proteomic Studies: Azidoethyl-SS-ethylamine is valuable in proteomic research for the labeling and identification of proteins. By tagging proteins with an azido group, researchers can employ click chemistry to attach reporter molecules that facilitate detection and quantification. This application is crucial for mapping protein interactions and elucidating cellular pathways.

Drug Delivery: Azidoethyl-SS-ethylamine can be used in the development of drug delivery systems. Its reactive groups allow for the creation of targeted delivery vectors such as nanoparticles or liposomes, which can specifically bind to diseased cells or tissues. This targeted approach enhances efficacy and reduces the side effects of therapeutic agents.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Historical Records: Propargyl-PEG1-SS-PEG1-PFP ester | Propargyl-PEG1-SS-PEG1-propargyl | Hydroxy-PEG3-SS-PEG3-alcohol | Propargyl-PEG1-SS-PEG1-acid | Acid-PEG3-SS-PEG3-acid | Propargyl-PEG1-SS-alcohol | Alkyne-SS-COOH | NHS-SS-Ph | Bis-(PEG6-acid)-SS | Azidoethyl-SS-ethylazide | Azidoethyl-SS-ethylamine
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