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Boc-NH-ethyl-SS-propionic acid

  CAS No.: 485800-27-9   Cat No.: BADC-01128   Purity: >98.0% 4.5  

Boc-NH-ethyl-SS-propionic acid is a cleavable ADC linker with Boc protection and disulfide bond, facilitating site-specific conjugation and controlled drug release in antibody-drug conjugates.

Boc-NH-ethyl-SS-propionic acid

Structure of 485800-27-9

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Category
ADC Linker
Molecular Formula
C10H19NO4S2
Molecular Weight
281.39
Shipping
Room temperature, or blue ice upon request.
Shipping
Store at -20 °C, keep in dry and avoid sunlight.

* For research and manufacturing use only. We do not sell to patients.

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Popular Publications Citing BOC Sciences Products
Synonyms
Boc-SS-Linker; 3-((2-((tert-Butoxycarbonyl)amino)ethyl)disulfanyl)propanoic acid; Propanoic acid, 3-[[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]dithio]-
IUPAC Name
Canonical SMILES
CC(C)(C)OC(=O)NCCSSCCC(=O)O
InChI
InChI=1S/C10H19NO4S2/c1-10(2,3)15-9(14)11-5-7-17-16-6-4-8(12)13/h4-7H2,1-3H3,(H,11,14)(H,12,13)
InChIKey
CIJZYVBXQKYUFA-UHFFFAOYSA-N
Solubility
10 mm in DMSO
Appearance
Solid
Shelf Life
-20°C 3 years powder; -80°C 2 years in solvent
Shipping
Room temperature, or blue ice upon request.
Storage
Store at -20 °C, keep in dry and avoid sunlight.
Form
Solid

Boc-NH-ethyl-SS-propionic acid, a synthetic compound with diverse applications in bioscience, particularly in peptide synthesis and pharmaceutical research. Here are four key applications presented with high perplexity and burstiness:

Peptide Synthesis: Serving as a fundamental component in peptide synthesis, Boc-NH-ethyl-SS-propionic acid plays a crucial role as a building block. By acting as a protective shield for the amino terminus, it shields against undesired side reactions when incorporating amino acids sequentially. This meticulous process ensures the production of impeccably pure peptides, essential for both research and therapeutic endeavors.

Drug Development: In the dynamic landscape of pharmaceutical research, Boc-NH-ethyl-SS-propionic acid emerges as a pivotal player in the creation of novel drugs, particularly those centered on peptide or protein structures. Its utility as a protective agent streamlines the development of intricate drug molecules with unparalleled specificity and potency. This innovation has the potential to unveil groundbreaking therapeutics for a myriad of medical conditions.

Bioconjugation: The versatile Boc-NH-ethyl-SS-propionic acid finds its niche in bioconjugation methodologies, acting as a facilitator in linking small molecules or therapeutic agents to larger biological entities like proteins or antibodies. This intricate process enhances the targeting efficiency of drugs and amplifies their therapeutic impact. Bioconjugation plays a pivotal role in the advancement of sophisticated therapeutic modalities such as antibody-drug conjugates (ADCs).

Chemical Biology: In the realm of chemical biology, Boc-NH-ethyl-SS-propionic acid emerges as a dynamic tool for probing and manipulating intricate biological systems. It enables the selective alteration of biological molecules, empowering researchers to methodically investigate the function and interactions of proteins and other biomolecules. This in-depth exploration contributes to a comprehensive understanding of complex biological processes and aids in the identification of potential drug targets, driving forward the frontiers of biomedical research.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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