Name: Boc-NH-PEG3-C2-triazole-DBCO-PEG4-VC-PAB-DMEA
Brand: BOC Sciences
Rating: 5 (1 reviews)

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IUPAC Name

Canonical SMILES

CC(C)C(C(=O)NC(CCCNC(=O)N)C(=O)NC1=CC=C(C=C1)COC(=O)N(C)CCNC)NC(=O)CCOCCOCCOCCOCCC(=O)NCCC(=O)N2CC3=CC=CC=C3C4=C(C5=CC=CC=C52)N(N=N4)CCOCCOCCOCCNC(=O)OC(C)(C)C

InChI

InChI=1S/C66H99N13O17/c1-47(2)58(62(84)73-53(16-12-25-70-63(67)85)61(83)72-50-20-18-48(19-21-50)46-95-65(87)77(7)29-27-68-6)74-56(81)24-32-89-36-40-93-44-43-92-39-35-88-31-23-55(80)69-26-22-57(82)78-45-49-13-8-9-14-51(49)59-60(52-15-10-11-17-54(52)78)79(76-75-59)30-34-91-38-42-94-41-37-90-33-28-71-64(86)96-66(3,4)5/h8-11,13-15,17-21,47,53,58,68H,12,16,22-46H2,1-7H3,(H,69,80)(H,71,86)(H,72,83)(H,73,84)(H,74,81)(H3,67,70,85)/t53-,58-/m0/s1

InChIKey

JYTHRLPETJLRBH-SRSCFSCASA-N

Solubility

10 mm in DMSO

Shelf Life

0-4°C for short term (days to weeks), or -20°C for long term (months).

Shipping

-20°C (International: -20°C)

Storage

Store at -20 °C, keep in dry and avoid sunlight.

Boc-NH-PEG3-C2-triazole-DBCO-PEG4-VC-PAB-DMEA, a versatile chemical linker, plays a pivotal role in crafting conjugated biomolecules.

Antibody-Drug Conjugates (ADCs): Employing this linker in ADC design and synthesis revolutionizes targeted cancer therapies, fusing antibodies with potent cytotoxic drugs. The linker guarantees stable attachment and controlled drug release within target cells, minimizing off-target effects. This precise delivery mechanism directly impacts cancer cells, elevating treatment precision and efficacy.

Protein Labeling and Modification: Embedded in site-specific protein labeling and modification, Boc-NH-PEG3-C2-triazole-DBCO-PEG4-VC-PAB-DMEA facilitates versatile conjugation to proteins with minimal impact on their biological functions. This capability is instrumental in studying protein interactions, fostering biosensor development, and advancing diagnostic assays.

Controlled Release Systems: The linker’s role in developing controlled drug release systems is paramount, enabling precise release kinetics under specific physiological conditions. By linking therapeutic agents to polymers or nanoparticles, the linker provides a pathway for enhancing therapeutic index and reducing drug-induced side effects through tailored release profiles.

Bioconjugation Reactions: In bioconjugation techniques like click chemistry, Boc-NH-PEG3-C2-triazole-DBCO-PEG4-VC-PAB-DMEA plays a crucial role in linking biomolecules efficiently and flexibly. This innovative approach allows for targeted modifications with high specificity and yield, paving the way for multifunctional diagnostics, imaging agents, and therapeutics for both research and clinical applications.