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Boc-D-trans-Hyp-OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). It is also an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| BADC-01919 | -- | $-- |
Boc-D-trans-Hyp-OH, a derivative of hydroxyproline utilized in peptide synthesis and drug development, boasts a multitude of applications. Here are four key applications expressed with a high degree of perplexity and burstiness:
Peptide Synthesis: Serving as a cornerstone in cyclic peptides and peptidomimetics synthesis, Boc-D-trans-Hyp-OH elevates stability and biological activity within peptide chains. This enhancement is paramount for the creation of peptide-based drugs and therapeutic agents, propelling advancements in medical treatments.
Collagen Research: Delving into the intricacies of collagen’s structure and function, Boc-D-trans-Hyp-OH stands as a pivotal player in collagen exploration. As hydroxyproline forms an integral part of collagen, its derivatives aid in crafting collagen-like peptides for in-depth structural investigations, shedding light on collagen-related ailments like osteogenesis imperfecta.
Drug Development: Spearheading the design and synthesis of proline-rich peptides for therapeutic applications, Boc-D-trans-Hyp-OH is a driving force in drug development. These peptides often exhibit enhanced pharmacokinetics and bioavailability, offering promising avenues for drug discovery. Through the integration of Boc-D-trans-Hyp-OH, researchers can forge potent and targeted drug candidates with increased efficacy.
Structural Biology: In the realm of structural biology, Boc-D-trans-Hyp-OH serves as a linchpin for unraveling the influence of hydroxyproline on protein folding and stability. By replacing natural amino acids with Boc-D-trans-Hyp-OH, scientists delve into the dynamics and interactions of proteins, illuminating the mechanisms underlying protein-related diseases. This profound grasp of protein behavior is essential for therapeutic protein development and combating complex diseases.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
