Boc-D-Aza-OH (CHA) - CAS 2098496-96-7

Boc-D-Aza-OH (CHA) - CAS 2098496-96-7 Catalog number: BADC-01762

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Boc-D-Aza-OH (CHA) is a click chemistry reagent containing an azide group.

Category
ADCs Linker
Product Name
Boc-D-Aza-OH (CHA)
CAS
2098496-96-7
Catalog Number
BADC-01762
Molecular Formula
C14H27N5O4
Molecular Weight
329.40

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Description
Boc-D-Aza-OH (CHA) is a click chemistry reagent containing an azide group.
Synonyms
Boc-D-Dap(N3) CHA
IUPAC Name
(2R)-3-azido-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid;cyclohexanamine
Canonical SMILES
CC(C)(C)OC(=O)NC(CN=[N+]=[N-])C(=O)O.C1CCC(CC1)N
InChI
InChI=1S/C8H14N4O4.C6H13N/c1-8(2,3)16-7(15)11-5(6(13)14)4-10-12-9;7-6-4-2-1-3-5-6/h5H,4H2,1-3H3,(H,11,15)(H,13,14);6H,1-5,7H2/t5-;/m1./s1
InChIKey
YDTIDHZIISJNBU-NUBCRITNSA-N

Boc-D-Aza-OH (CHA) is widely used in peptide synthesis as a protecting group for the amino function. This N-Boc-protected azetidine derivative ensures that the amino group remains unreactive during various synthetic steps while allowing for selective deprotection at a later stage. The use of Boc-D-Aza-OH (CHA) in peptide synthesis enhances the overall efficiency and specificity of the process, making it an essential compound for the development of complex peptides and proteins. Its stability under both acidic and basic conditions adds to its versatility in synthetic applications.

In medicinal chemistry, Boc-D-Aza-OH (CHA) is employed in the design and synthesis of enzyme inhibitors and receptor antagonists. By incorporating this compound into the molecular framework, researchers can explore new avenues in drug discovery and development. The unique structural attributes of Boc-D-Aza-OH (CHA) contribute to its ability to interact with biological targets in a highly selective manner, thus paving the way for the creation of novel therapeutic agents. This application is particularly important in the development of drugs targeting proteases, kinases, and other critical enzymes involved in disease pathogenesis.

Boc-D-Aza-OH (CHA) finds significant use in the field of chemical biology, especially in the study of protein-protein interactions. By utilizing this compound as a building block, scientists can generate peptide mimetics that modulate or inhibit specific protein interactions. This capability is crucial for understanding cellular processes and for the development of tools that can probe or alter biological systems with high precision. The versatility of Boc-D-Aza-OH (CHA) thus makes it a valuable resource in the toolbox of chemical biologists working on intricate biological questions.

Additionally, Boc-D-Aza-OH (CHA) is instrumental in the development of bioactive natural product analogs. Researchers use this compound to modify and improve the properties of natural products, which often serve as lead compounds in drug discovery. By integrating Boc-D-Aza-OH (CHA) into the structure of natural products, it is possible to enhance their stability, bioavailability, and target specificity. This application not only broadens the scope of natural product research but also contributes to the identification of promising candidates for therapeutic development.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Historical Records: Boc-D-Aza-OH (CHA)
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