Name: Sulfo-SPDP-C6-NHS sodium
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Synonyms

Sulfo-N-succinimidyl 6-[3-(2-Pyridyldithio)propionamido] Hexanoate, Sodium Salt; Sulfo-LC-SPDP Crosslinker; SPDP-C6-Sulfo-NHS ester

IUPAC Name

Canonical SMILES

C1C(C(=O)N(C1=O)OC(=O)CCCCCNC(=O)CCSSC2=CC=CC=N2)S(=O)(=O)[O-].[Na+]

InChI

InChI=1S/C18H23N3O8S3.Na/c22-14(8-11-30-31-15-6-3-5-10-20-15)19-9-4-1-2-7-17(24)29-21-16(23)12-13(18(21)25)32(26,27)28;/h3,5-6,10,13H,1-2,4,7-9,11-12H2,(H,19,22)(H,26,27,28);/q;+1/p-1

InChIKey

ZAPNXDUFCQIHFS-UHFFFAOYSA-M

Density

1.53g/cm3

Solubility

10 mm in DMSO

Melting Point

185-187°C

Index Of Refraction

1.64

PSA

221.85000

Appearance

White to off-white solid

Shelf Life

0-4°C for short term (days to weeks), or -20°C for long term (months).

Shipping

Room temperature

Storage

Store at -20 °C, keep in dry and avoid sunlight.

Pictograms

Irritant

Signal Word

Warning

Form

Solid

Sulfo-SPDP-C6-NHS sodium is a highly effective ADC linker designed for advanced antibody-drug conjugate (ADC) development and targeted cancer therapies. As a water-soluble ADC linker, Sulfo-SPDP-C6-NHS sodium facilitates efficient conjugation between monoclonal antibodies and diverse ADC cytotoxins, enabling precise delivery of payloads to tumor cells. Its chemical structure includes an NHS ester and a cleavable disulfide bridge, allowing site-specific bioconjugation and controlled intracellular release of ADC payloads. This feature is critical in modern ADC linker design, balancing systemic stability with efficient payload release in the tumor microenvironment while maintaining antibody functionality and antigen-binding specificity.

Sulfo-SPDP-C6-NHS sodium supports the conjugation of a wide range of ADC cytotoxins, including microtubule inhibitors, DNA-targeting drugs, and other potent payloads. Its cleavable disulfide linkage ensures selective intracellular release upon exposure to the reducing environment inside tumor cells, enhancing therapeutic efficacy and minimizing systemic toxicity. The linker’s water solubility improves handling and reaction efficiency in aqueous conditions, making it suitable for both laboratory research and large-scale industrial ADC production. By incorporating this linker, researchers can achieve controlled and reproducible bioconjugation, essential for constructing homogeneous ADC payload conjugates with optimal pharmacokinetics and target specificity.

In practical applications, Sulfo-SPDP-C6-NHS sodium is widely used in oncology-focused ADC research, bioconjugation studies, and targeted drug delivery systems. Its chemical versatility and cleavable disulfide bridge enable modular ADC linker design strategies, supporting both preclinical research and scalable therapeutic development. The linker’s ability to maintain antibody structure and functionality while enabling efficient intracellular payload release enhances tumor-specific drug delivery. Sulfo-SPDP-C6-NHS sodium is therefore a crucial component for constructing next-generation ADCs, providing flexibility, reliability, and enhanced performance in targeted cancer therapy and bioconjugation applications.

Catalog	Product Name	CAS
BADC-00459	SPDP-PEG8-NHS	1252257-56-9
BADC-00497	sulfo-LC-SPDP	150244-18-1
BADC-00508	SPDPH	158913-22-5
BADC-00011	DM4-SPDP	2245698-48-8
BADC-01092	PC SPDP-NHS carbonate ester	2279944-61-3
BADC-00372	SPDP	68181-17-9
BADC-01315	SPDP-C6-Gly-Leu-NHS ester
BADC-01316	SPDP-PEG12-acid
BADC-01317	SPDP-PEG36-NHS ester

What is Sulfo-SPDP-C6-NHS sodium and its application in ADCs?

Sulfo-SPDP-C6-NHS sodium is a water-soluble heterobifunctional linker with an NHS ester and a pyridyldithiol group. It facilitates selective antibody-payload conjugation and provides a disulfide-based cleavable linkage for controlled intracellular release.

5/7/2022

Dear team, how does Sulfo-SPDP-C6-NHS sodium enable cleavable conjugation?

The pyridyldithiol group forms a reducible disulfide bond with thiol-containing payloads, which remains stable in circulation but is cleaved in the reducing environment of target cells, releasing the payload selectively.

17/12/2018

Dear team, which payloads can be conjugated using Sulfo-SPDP-C6-NHS sodium?

It is compatible with cytotoxic drugs, peptides, and proteins with free thiols. The sulfonate group improves water solubility, while the C6 spacer provides flexibility to reduce steric hindrance during conjugation.

16/3/2022

Good morning! Could you please let me know the optimal conjugation conditions for Sulfo-SPDP-C6-NHS sodium?

Conjugation is performed in aqueous buffers (pH 7–8) at controlled temperatures to preserve the NHS ester and pyridyldithiol reactivity while achieving efficient and stable antibody-payload conjugation.

24/7/2018

Good afternoon! What quality control tests are provided for Sulfo-SPDP-C6-NHS sodium?

BOC Sciences provides Sulfo-SPDP-C6-NHS sodium with full quality control including mass spectrometry, NMR, and solubility tests. These confirm chemical identity and functional integrity. The supporting documentation allows researchers to validate the product’s suitability for conjugation reactions and ensures reproducibility in ADC development.

19/7/2022

— Dr. Michael Scott, Senior Chemist (USA)

Sulfo-SPDP-C6-NHS sodium offered exceptional water solubility and smooth thiol conjugation for our ADC studies.

16/3/2022

— Ms. Emily Fischer, Biochemist (Germany)

Batch-to-batch consistency was excellent, and Sulfo-SPDP-C6-NHS sodium simplified our multi-step workflows.

19/7/2022

— Dr. Thomas White, ADC Scientist (UK)

Using Sulfo-SPDP-C6-NHS sodium, we obtained high yields with minimal side reactions, improving efficiency.

24/7/2018

— Dr. Isabelle Laurent, Medicinal Chemist (France)

Sulfo-SPDP-C6-NHS sodium performed reliably across various conjugation protocols.

5/7/2022

— Dr. Helena Meyer, Research Scientist (Germany)

The reagent helped streamline linker assembly, enabling faster development of novel ADC constructs.

— Dr. Andrew Mitchell, Bioconjugation Scientist (USA)

Sulfo-SPDP-C6-NHS sodium from BOC Sciences arrived on time and exhibited excellent solubility for our conjugation reactions. Their support team guided us on optimal handling conditions.

17/12/2018