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DM4-SPDP

  CAS No.: 2245698-48-8   Cat No.: BADC-00011   Purity: ≥98% 4.5  

DM4 with a reactive linker SPDP, which can react with antibody to make antibody drug conjugate. DM4 can bind to tubulin at or near the vinblastine-binding site.

DM4-SPDP

Structure of 2245698-48-8

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Category
ADC Cytotoxin
Molecular Formula
C45H61ClN4O14S2
Molecular Weight
981.57
Shipping
Room temperature

* For research and manufacturing use only. We do not sell to patients.

Size Price Stock Quantity
1 mg $299 In stock

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Synonyms
Maytansinoid DM4- succinimidyl 3-(2-pyridyldithio)propionate; DM4 SPDP
IUPAC Name
[(2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] (2S)-2-[[4-[[3-(2,5-dioxopyrrolidin-1-yl)oxy-3-oxopropyl]disulfanyl]-4-methylpentanoyl]-methylamino]propanoate
Canonical SMILES
CC1C2CC(C(C=CC=C(CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)CC(C4(C1O4)C)OC(=O)C(C)N(C)C(=O)CCC(C)(C)SSCCC(=O)ON5C(=O)CCC5=O)C)C)OC)(NC(=O)O2)O
InChI
InChI=1S/C45H61ClN4O14S2/c1-25-12-11-13-32(60-10)45(58)24-31(61-42(57)47-45)26(2)40-44(6,63-40)33(23-37(54)49(8)29-21-28(20-25)22-30(59-9)39(29)46)62-41(56)27(3)48(7)34(51)16-18-43(4,5)66-65-19-17-38(55)64-50-35(52)14-15-36(50)53/h11-13,21-22,26-27,31-33,40,58H,14-20,23-24H2,1-10H3,(H,47,57)/b13-11+,25-12+/t26-,27+,31?,32-,33+,40+,44+,45+/m1/s1
Appearance
Soild powder
Shipping
Room temperature
Form
Solid

DM4-SPDP, an potent cytotoxic agent linked to antibodies via a cleavable linker, plays a pivotal role in targeted cancer therapies. Here are four key applications of DM4-SPDP:

Antibody-Drug Conjugates (ADCs): Utilizing DM4-SPDP in the development of ADCs represents a cutting-edge approach to delivering cytotoxic drugs directly to cancerous cells. By conjugating DM4 to monoclonal antibodies that specifically target antigens on tumor cells, this strategy minimizes harm to normal tissues. The precision of this targeted therapy not only boosts the effectiveness of cancer treatments but also enhances their safety profile significantly.

Bioconjugation Research: In the realm of bioconjugation studies, researchers harness DM4-SPDP for crafting innovative drug delivery systems. The cleavable linker SPDP allows for precise release of the drug at the intended target location. This unique property proves critical for optimizing drug stability and fine-tuning release kinetics, particularly in therapeutic settings where precision is paramount.

Preclinical Cancer Models: DM4-SPDP finds extensive use in preclinical cancer models aimed at elucidating the mechanisms of action and resistance in cancer treatment. By incorporating it into diverse in vitro and in vivo models, scientists can thoroughly assess the anti-cancer efficacy of this compound while also evaluating potential side effects. These comprehensive studies serve as a vital stepping stone for advancing ADCs from preclinical research to pivotal clinical trials.

Synthetic Organic Chemistry: Beyond oncology, DM4-SPDP plays a key role in synthetic organic chemistry, offering a versatile tool for creating functionalized molecules. Its unique ability to form stable yet cleavable linkages makes it invaluable in constructing intricate molecular structures. Capitalizing on these distinctive properties, researchers leverage DM4-SPDP to design and synthesize groundbreaking therapeutics and diagnostic agents, pushing the boundaries of innovation in synthetic chemistry.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Historical Records: SPDP | Fmoc-Val-Cit-PAB | Tubulysin IM-3 | Nitro-PDS-Tubulysin M | Mertansine | DBCO-NHS ester | Tubulysin A | Tubulysin B | PAC | MC-VC-PABC-DNA31 | DM4-SPDP
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