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DM4 with a reactive linker SPDP, which can react with antibody to make antibody drug conjugate. DM4 can bind to tubulin at or near the vinblastine-binding site.
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-00011 | 1 mg | $299 | Inquiry |
DM4-SPDP, an potent cytotoxic agent linked to antibodies via a cleavable linker, plays a pivotal role in targeted cancer therapies. Here are four key applications of DM4-SPDP:
Antibody-Drug Conjugates (ADCs): Utilizing DM4-SPDP in the development of ADCs represents a cutting-edge approach to delivering cytotoxic drugs directly to cancerous cells. By conjugating DM4 to monoclonal antibodies that specifically target antigens on tumor cells, this strategy minimizes harm to normal tissues. The precision of this targeted therapy not only boosts the effectiveness of cancer treatments but also enhances their safety profile significantly.
Bioconjugation Research: In the realm of bioconjugation studies, researchers harness DM4-SPDP for crafting innovative drug delivery systems. The cleavable linker SPDP allows for precise release of the drug at the intended target location. This unique property proves critical for optimizing drug stability and fine-tuning release kinetics, particularly in therapeutic settings where precision is paramount.
Preclinical Cancer Models: DM4-SPDP finds extensive use in preclinical cancer models aimed at elucidating the mechanisms of action and resistance in cancer treatment. By incorporating it into diverse in vitro and in vivo models, scientists can thoroughly assess the anti-cancer efficacy of this compound while also evaluating potential side effects. These comprehensive studies serve as a vital stepping stone for advancing ADCs from preclinical research to pivotal clinical trials.
Synthetic Organic Chemistry: Beyond oncology, DM4-SPDP plays a key role in synthetic organic chemistry, offering a versatile tool for creating functionalized molecules. Its unique ability to form stable yet cleavable linkages makes it invaluable in constructing intricate molecular structures. Capitalizing on these distinctive properties, researchers leverage DM4-SPDP to design and synthesize groundbreaking therapeutics and diagnostic agents, pushing the boundaries of innovation in synthetic chemistry.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
